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Peptide record

TPDB10127

Antibacterial Anticancer Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10127
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia CancerPPD 2.0 dbACP AFP-GFuse
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
RKKRRQRRRLNLKALLAVAKKIL
Physicochemical Analysis
C125H238N48O26
DCEGHMFPSTWY
R
2829.57
13.11
11
0
10
+11
7.26
-0.887
127.39
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
3
A
6
R
1
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
5
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 6 N: 1 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 5 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C125H238N48O26
2829.57
13.11
+11
7.26
-0.887
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
9.18 µM
Cytotoxic
IC50 | 9.18 | µM | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. | Int J Biol Sci | 2018
Evidence 2 Activity

Activity

50% hemolysis
Toxicity
77.94 µM
Hemolytic Cytotoxic
50% hemolysis | 77.94 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Evaluation of the bioactivity of a mastoparan peptide from wasp venom and of its analogues designed through targeted engineering. | Int J Biol Sci | 2018
Evidence 3 Activity

Activity

IC50
Toxicity
9.18 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.29904274]50% hemolysis against horse erythrocytes at 77.94 µM. | Cytotoxicity: [Ref.29904274]Cytotoxicity:Human microvascular endothelial cells HMEC-1(IC50=9.18 µM).

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Biol Sci. 2018 Apr 25 14(6):599-607.