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Peptide record

TPDB10126

Antibacterial Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10126
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RKHGFLNLQGIFGDYYHFWHRGV
Physicochemical Analysis
C136H187N39O30
ACEMPST
G
2848.22
10.08
6
1
10
+2
-0.72
-0.583
63.48
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
8480
297.73
4
Residue Composition
number
0
A
2
R
1
N
1
D
0
C
0
E
1
Q
4
G
3
H
1
I
2
L
1
K
0
M
3
F
0
P
0
S
0
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 4 H: 3 I: 1 L: 2 K: 1 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 2 V: 1
Chemical Descriptors
23
C136H187N39O30
2848.22
10.08
+2
-0.72
-0.583
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli

Source & Reference

NA

Other

active against E. coli (MIC 4 uM), P.aeruginosa (MIC >100 uM) S.enterica (MIC >100 uM) K.pneumoniae (MIC >100 uM) S.aure
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.aeruginosa

Source & Reference

NA

Other

active against E. coli (MIC 4 uM), P.aeruginosa (MIC >100 uM) S.enterica (MIC >100 uM) K.pneumoniae (MIC >100 uM) S.aureus (MIC >100 uM) B.subtilis
Evidence 3 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.enterica

Source & Reference

NA

Other

active against E. coli (MIC 4 uM), P.aeruginosa (MIC >100 uM) S.enterica (MIC >100 uM) K.pneumoniae (MIC >100 uM) S.aureus (MIC >100 uM) B.subtilis (MIC >100 uM) S.pyogenes
Evidence 4 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae

Source & Reference

NA

Other

active against E. coli (MIC 4 uM), P.aeruginosa (MIC >100 uM) S.enterica (MIC >100 uM) K.pneumoniae (MIC >100 uM) S.aureus (MIC >100 uM) B.subtilis (MIC >100 uM) S.pyogenes (MIC >100 uM) and E.faecal
Evidence 5 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.aureus

Source & Reference

NA

Other

4 uM), P.aeruginosa (MIC >100 uM) S.enterica (MIC >100 uM) K.pneumoniae (MIC >100 uM) S.aureus (MIC >100 uM) B.subtilis (MIC >100 uM) S.pyogenes (MIC >100 uM) and E.faecalis (MIC >100 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
>100 µM

Target

B.subtilis

Source & Reference

NA

Other

C >100 uM) S.enterica (MIC >100 uM) K.pneumoniae (MIC >100 uM) S.aureus (MIC >100 uM) B.subtilis (MIC >100 uM) S.pyogenes (MIC >100 uM) and E.faecalis (MIC >100 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.pyogenes

Source & Reference

NA

Other

C >100 uM) K.pneumoniae (MIC >100 uM) S.aureus (MIC >100 uM) B.subtilis (MIC >100 uM) S.pyogenes (MIC >100 uM) and E.faecalis (MIC >100 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
>100 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

>100 uM) S.aureus (MIC >100 uM) B.subtilis (MIC >100 uM) S.pyogenes (MIC >100 uM) and E.faecalis (MIC >100 uM).
Evidence 9 Activity

Activity

40% hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
40% hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics. | ACS Omega | 2018
Evidence 10 Activity

Activity

55% Hemolysis
Toxicity
150 µM
Hemolytic Cytotoxic
55% Hemolysis | 150 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cell-Selective Pore Forming Antimicrobial Peptides of the Prodomain of Human Furin: A Conserved Aromatic/Cationic Sequence Mapping, Membrane Disruption, and Atomic-Resolution Structure and Dynamics. | ACS Omega | 2018