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Peptide record

TPDB10124

Antibacterial Hemolysis Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB10124
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia PD_Hemolysis
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RIGSILGRLAKGLPTLISWIKNR
Physicochemical Analysis
C117H204N36O28
DCEQHMFYV
IL
2563.13
12.71
5
0
10
+5
0.21
0.183
140.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
214.58
4
Residue Composition
number
1
A
3
R
1
N
0
D
0
C
0
E
0
Q
3
G
0
H
4
I
4
L
2
K
0
M
0
F
1
P
2
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 0 I: 4 L: 4 K: 2 M: 0 F: 0 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
23
C117H204N36O28
2563.13
12.71
+5
0.21
0.183
Evidence Records 3 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
10% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of an ?-helical antimicrobial peptide with improved cell-selective and potent anti-biofilm activity. | Sci Rep | 2016
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
58 %
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27271216] 58% hemolysis at 20 µM , 80% hemolysis at 40 µM , 100% hemolysis at 60 µM against human red blood cells | Cytotoxicity: [Ref.27271216] In L929 cells, the cell viability is 92%, 80%, 29%, 1% and almost 0% at peptide concentrations of 3.12, 6.25, 12.5, 25 and 50 µM.

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2016 Jun 8 6:27394. doi: 10.1038/srep27394.
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis