Back to search

Peptide record

TPDB10121

Antibacterial Anticancer Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10121
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RRIRPRPPRLPRPRPRPLPFPRP
Physicochemical Analysis
C131H222N50O24
ANDCEQGHKMSTWYV
P
2881.52
13.30
9
0
4
+9
9.23
-1.809
50.87
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
2
L
0
K
0
M
1
F
10
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 2 K: 0 M: 0 F: 1 P: 10 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
23
C131H222N50O24
2881.52
13.30
+9
9.23
-1.809
Evidence Records 8 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

Escherichia coli ATCC 25922 or ML-35

Source & Reference

NA

Other

active against E. coli ATCC 25922 or ML-35 (MIC 1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2 uM), S. marcescens ATCC8100 (MIC 4 uM)
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

S. enterica serovar Typhimurium ATCC 14028

Source & Reference

NA

Other

active against E. coli ATCC 25922 or ML-35 (MIC 1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2 uM), S. marcescens ATCC8100 (MIC 4 uM), S.aureus ATCC 25923 (MIC >128 uM). Updated 8/2024
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

S. marcescens ATCC8100

Source & Reference

NA

Other

li ATCC 25922 or ML-35 (MIC 1 uM), S. enterica serovar Typhimurium ATCC 14028 (MIC 2 uM), S. marcescens ATCC8100 (MIC 4 uM), S.aureus ATCC 25923 (MIC >128 uM). Updated 8/2024
Evidence 4 Activity

Activity

MIC
Antibacterial
>128 µM

Target

S.aureus ATCC 25923

Source & Reference

NA

Other

S. enterica serovar Typhimurium ATCC 14028 (MIC 2 uM), S. marcescens ATCC8100 (MIC 4 uM), S.aureus ATCC 25923 (MIC >128 uM). Updated 8/2024
Evidence 5 Activity

Activity

2.1% Hemolysis
Toxicity
2.8 µM
Hemolytic Cytotoxic
2.1% Hemolysis | 2.8 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. | BMC Biol | 2022
Evidence 6 Activity

Activity

6.4% Hemolysis
Toxicity
11.2 µM
Hemolytic Cytotoxic
6.4% Hemolysis | 11.2 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. | BMC Biol | 2022
Evidence 7 Activity

Activity

IC50
Toxicity
1970 µM
Cytotoxic
IC50 | 1970 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Optimization of the antimicrobial peptide Bac7 by deep mutational scanning. | BMC Biol | 2022
Evidence 8 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
BMC Biol. 2022 May 16 20(1):114.