TPDB

3D PDB MODEL

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TPDB ID TPDB10099

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLWQKIKNAAGDLASGIVEGIKS

FASTA

>TPDB10099|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=23
GLWQKIKNAAGDLASGIVEGIKS

Formula C105H175N29O32

Absent Amino Acids RCHMFPTY

Common Amino Acids G

Mass 2355.72

PI 9.76

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 10

Net Charge +1

Boman Index 3.18

Hydrophobicity 0.039

Aliphatic Index 110.43

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 233.47

Polar Residues 4

number

3

A

0

R

1

N

1

D

0

C

1

E

1

Q

4

G

0

H

3

I

2

L

3

K

0

M

0

F

0

P

2

S

0

T

1

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 1 G: 4 H: 0 I: 3 L: 2 K: 3 M: 0 F: 0 P: 0 S: 2 T: 0 W: 1 Y: 0 V: 1

Length

23

Formula

C105H175N29O32

Mass

2355.72

PI

9.76

Net Charge

+1

Boman Index

3.18

Hydrophobicity

0.039

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Activity against M. luteus (MIC 25 ug/ml) and E. coli (MIC 50 ug/ml). Updated 7/2021.

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against M. luteus (MIC 25 ug/ml) and E. coli (MIC 50 ug/ml). Updated 7/2021.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Activity against M. luteus (MIC 25 ug/ml) and E. coli (MIC 50 ug/ml). Updated 7/2021.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against M. luteus (MIC 25 ug/ml) and E. coli (MIC 50 ug/ml). Updated 7/2021.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µg/mL

Target

Target Organism M. luteus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Activity against M. luteus (MIC 25 ug/ml) and E. coli (MIC 50 ug/ml). Updated 7/2021.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 50 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against M. luteus (MIC 25 ug/ml) and E. coli (MIC 50 ug/ml). Updated 7/2021.