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Peptide record

TPDB10049

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB10049
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLGSIVGALASALPSLISKIRN
Physicochemical Analysis
C102H175N27O28
DCEQHMTWY
LS
2227.68
11.49
2
0
12
+2
-1.53
1.073
150.91
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
5
Residue Composition
number
3
A
1
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
4
L
1
K
0
M
1
F
1
P
4
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 4 K: 1 M: 0 F: 1 P: 1 S: 4 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C102H175N27O28
2227.68
11.49
+2
-1.53
1.073
Evidence Records 32 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae
Evidence 2 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP

Other

Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aer
Evidence 3 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

dbAMP DRAMP

Other

C 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. al
Evidence 5 Activity

Activity

MIC
Antibacterial
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP

Other

/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneu
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP

Other

0 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

K.pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP

Other

50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae
Evidence 9 Activity

Activity

MIC
Antifungal
25 µM

Target

Escherichia coli ATCC25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aer
Evidence 10 Activity

Activity

MIC
Antifungal
50 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

C 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus
Evidence 11 Activity

Activity

MIC
Antifungal
50 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. al
Evidence 12 Activity

Activity

MIC
Antifungal
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneu
Evidence 13 Activity

Activity

MIC
Antifungal
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

0 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
>100 µM

Target

K.pneumoniae KK3 9904

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae
Evidence 16 Activity

Activity

MIC
Antiparasitic
25 µM

Target

Escherichia coli ATCC25922

Source & Reference

DRAMP

Other

Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aer
Evidence 17 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

DRAMP

Other

C 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus
Evidence 18 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. al
Evidence 19 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneu
Evidence 20 Activity

Activity

MIC
Antiparasitic
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

DRAMP

Other

0 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 21 Activity

Activity

MIC
Antiparasitic
>100 µM

Target

K.pneumoniae KK3 9904

Source & Reference

DRAMP

Other

50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 22 Activity

Activity

MIC
Antiviral
12.5 µM

Target

Staphylococcus epidermidis RP62A

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae
Evidence 23 Activity

Activity

MIC
Antiviral
25 µM

Target

Escherichia coli ATCC25922

Source & Reference

DRAMP

Other

Much less active than 2TSa (AP587). active against S. epidermidis RP62A (MIC 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aer
Evidence 24 Activity

Activity

MIC
Antiviral
50 µM

Target

Enterobacter cloacae HNTCC 5300

Source & Reference

DRAMP

Other

C 12.5 uM), E. coli ATCC25922 (MIC 25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus
Evidence 25 Activity

Activity

MIC
Antiviral
50 µM

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

DRAMP

Other

25 uM), S. aureus NCTC 8325 or MRSA T7/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. al
Evidence 26 Activity

Activity

MIC
Antiviral
50 µM

Target

Enterococcus faecalis ATCC 29212

Source & Reference

DRAMP

Other

/20 (MIC 25 uM), E. cloacae HNTCC 5300 (MIC 50 uM), P. aeruginosa ATCC 27853 (MIC 50 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneu
Evidence 27 Activity

Activity

MIC
Antiviral
50 µM

Target

Candida albicans ATCC 90028

Source & Reference

DRAMP

Other

0 uM), E. faecalis ATCC 29212 (MIC 50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 28 Activity

Activity

MIC
Antiviral
>100 µM

Target

K.pneumoniae KK3 9904

Source & Reference

DRAMP

Other

50 uM), Streptococcus group B HNTCC 80130 (MIC 50 uM), C. albicans ATCC 90028 (MIC 50 uM),K.pneumoniae KK3 9904 (MIC>100 uM), P.mirabilis ATCC 25933 (MIC > 100 uM).
Evidence 29 Activity

Activity

Hemolysis
[Ref.16413829]LD50=12 µM against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Comp Biochem Physiol C Toxicol Pharmacol. 2006 May 143(1):42-49.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 30 Activity

Activity

50% Hemolysis
Toxicity
12 µM
Hemolytic Cytotoxic
50% Hemolysis | 12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial peptides from the skin of the Tsushima brown frog Rana tsushimensis. | Comp Biochem Physiol C Toxicol Pharmacol | 2006
Evidence 31 Activity

Activity

LD50
Toxicity
12 µM
Hemolytic
Hemolytic_activity: [Ref.16413829]LD50=12 µM against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Comp Biochem Physiol C Toxicol Pharmacol. 2006 May 143(1):42-49.
Evidence 32 Hemolysis

Activity

[Ref.16413829]LD50=12 µM against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Comp Biochem Physiol C Toxicol Pharmacol. 2006 May 143(1):42-49.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.