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Peptide record

TPDB10043

Antibacterial Anticancer Antifungal Antiparasitic standard

22 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB10043

Activity

Antibacterial Anticancer Antifungal Antiparasitic

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLWEKVKEKANELVSGIVEGVK

FASTA

>TPDB10043|Antibacterial;Anticancer;Antifungal;Antiparasitic|length=22
GLWEKVKEKANELVSGIVEGVK

Formula C109H182N28O33

Absent Amino Acids RDCQHMFPTY

Common Amino Acids EKV

Mass 2412.81

PI 7.17

Basic Residues 4

Acidic Residues 4

Hydrophobic Residues 9

Net Charge +0

Boman Index 9.45

Hydrophobicity -0.241

Aliphatic Index 110.45

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 5500

Absorbance 280nm 227.95

Polar Residues 2

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 0 C: 0 E: 4 Q: 0 G: 3 H: 0 I: 1 L: 2 K: 4 M: 0 F: 0 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 4

Length

Formula

C109H182N28O33

Mass

2412.81

7.17

Net Charge

Boman Index

9.45

Hydrophobicity

-0.241

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (M

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 100 µM

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

tivity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

00 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

nnocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.uberis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

us (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/m

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism E.clocae

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

s ATCC 25923 (MIC >100 ug/ml), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

l), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021 12/2024

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism P.haemolytica

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021 12/2024

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (M

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 100 µM

Target

Target Organism L. lactis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.uberis

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism E.clocae

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

l), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021 12/2024

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism P.haemolytica

Source & Reference

Database Source dbAMP DRAMP Antifungipept

Other

Evidence Text

), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021 12/2024

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism B.cereus

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (M

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 100 µM

Target

Target Organism L. lactis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Activity against B.cereus (MIC >100 ug/ml), E.coli (MIC>100 ug/ml), L. lactis (MIC 100 uM), L.innocua (MIC >100 ug/ml), M. luteus (MIC >100 ug/ml, S.aureus ATCC 25923 (MIC >100 ug/

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism L.innocua

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus ATCC 25923

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.epidermidis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.uberis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism E.clocae

Source & Reference

Database Source DRAMP

Other

Evidence Text

Evidence 29 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism P.multocida

Source & Reference

Database Source DRAMP

Other

Evidence Text

l), S.epidermidis (MIC >100 ug/ml), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021 12/2024

Evidence 30 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism P.haemolytica

Source & Reference

Database Source DRAMP

Other

Evidence Text

), S.uberis (MIC >100 ug/ml), E.clocae (MIC >100 ug/ml), P.multocida (MIC>100 ug/ml), and P.haemolytica (MIC >100 ug/ml). Updated 5/2020, 7/2021 12/2024