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Peptide record

TPDB10040

Piscidin 3 Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB10040
Piscidin 3
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP AI4AVP dbAMP 3.0 DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FIHHIFRGIVHAGRSIGRFLTG
Physicochemical Analysis
C116H179N37O25
NDCEQKMPWY
GI
2491.93
12.70
6
0
10
+3
0.33
0.455
106.36
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
4
G
3
H
4
I
1
L
0
K
0
M
3
F
0
P
1
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 3 I: 4 L: 1 K: 0 M: 0 F: 3 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C116H179N37O25
2491.93
12.70
+3
0.33
0.455
Free
L
Linear
Free
Anticancer
Morone chrysops x Morone saxatilis
Evidence Records 34 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.51 µM

Target

S. iniae

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26
Evidence 2 Activity

Activity

MIC
Antibacterial
20.07 µM

Target

L. garvieae

Source & Reference

dbAMP DRAMP

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. fae
Evidence 3 Activity

Activity

MIC
Antibacterial
2.51-5.02 µM

Target

V. anguillarum

Source & Reference

dbAMP DRAMP

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (M
Evidence 4 Activity

Activity

MIC
Antibacterial
1.26 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP

Other

07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against ch
Evidence 5 Activity

Activity

MIC
Antibacterial
20.07 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP

Other

2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), f
Evidence 6 Activity

Activity

MIC
Antibacterial
80.26 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

IC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), frog virus 3 (FV3) (Chinchar
Evidence 7 Activity

Activity

IC50
IC50 = 26.01 µM
Anticancer
26.01 µM

Target

Fibrosarcoma
HT-1080
Not Available

Assay & Model

MTT assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0
CancerPPD2
2021

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation. dbAMP 3.0 classified as Anticancer under the disease-associated peptide function classes.
Evidence 8 Activity

Activity

IC50
IC50 = 17.5 µM
Anticancer
17.5 µM

Target

Breast Cancer
MDA-MB-231
Breast

Assay & Model

MTT assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0
CancerPPD2
2021
Evidence 9 Activity

Activity

IC50
IC50 = 21.6 µM
Anticancer
21.6 µM

Target

Lung Cancer
A-549
Lung

Assay & Model

MTT assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0
CancerPPD2
2021
Evidence 10 Activity

Activity

IC50
IC50 = 18.1 µM
Anticancer
18.1 µM

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

MTT assay
24-h

Source & Reference

dbAMP 3.0 CancerPPD 2.0
CancerPPD2
2021
Evidence 11 Activity

Activity

MIC
Antifungal
2.51 µM

Target

S. iniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26
Evidence 12 Activity

Activity

MIC
Antifungal
20.07 µM

Target

L. garvieae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. fae
Evidence 13 Activity

Activity

MIC
Antifungal
2.51-5.02 µM

Target

V. anguillarum

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (M
Evidence 14 Activity

Activity

MIC
Antifungal
1.26 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against ch
Evidence 15 Activity

Activity

MIC
Antifungal
20.07 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), f
Evidence 16 Activity

Activity

MIC
Antifungal
80.26 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

IC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), frog virus 3 (FV3) (Chinchar
Evidence 17 Activity

Activity

MIC
Antiparasitic
2.51 µM

Target

S. iniae

Source & Reference

dbAMP 3.0 DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.
fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26
Evidence 18 Activity

Activity

MIC
Antiparasitic
20.07 µM

Target

L. garvieae

Source & Reference

dbAMP 3.0 DRAMP

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. fae
Evidence 19 Activity

Activity

MIC
Antiparasitic
2.51-5.02 µM

Target

V. anguillarum

Source & Reference

dbAMP 3.0 DRAMP

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (M
Evidence 20 Activity

Activity

MIC
Antiparasitic
1.26 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP

Other

07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against ch
Evidence 21 Activity

Activity

MIC
Antiparasitic
20.07 µM

Target

S. flexneri

Source & Reference

dbAMP 3.0 DRAMP

Other

2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), f
Evidence 22 Activity

Activity

MIC
Antiparasitic
80.26 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP

Other

IC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), frog virus 3 (FV3) (Chinchar
Evidence 23 Activity

Activity

MIC
Antiviral
2.51 µM

Target

S. iniae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.
fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26
Evidence 24 Activity

Activity

MIC
Antiviral
20.07 µM

Target

L. garvieae

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. fae
Evidence 25 Activity

Activity

MIC
Antiviral
2.51-5.02 µM

Target

V. anguillarum

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

fish pathogens S. iniae (MIC 2.51 uM), L. garvieae (MIC 20.07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (M
Evidence 26 Activity

Activity

MIC
Antiviral
1.26 µM

Target

Enterococcus faecalis

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

07 uM), V. anguillarum (MIC 2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against ch
Evidence 27 Activity

Activity

MIC
Antiviral
20.07 µM

Target

S. flexneri

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

2.51-5.02 uM), A-salmonicida (MIC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), f
Evidence 28 Activity

Activity

MIC
Antiviral
80.26 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0 DRAMP DRAVP 2.0

Other

IC >80.26 uM), human pathogens E. faecalis (MIC 1.26 uM), S. flexneri (MIC 20.07 uM), and E. coli (MIC 80.26 uM). Viruses: It is active against channel catfish virus (CCV), frog virus 3 (FV3) (Chinchar
Evidence 29 Activity

Activity

% Hemolysis
Hemolysis
5 %
[Ref.11713517]5% hemolytic activity at 100 µg/mL against human erythrocytes

Target

human erythrocytes

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Nature. 2001 Nov 15 414(6861):268-269.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 30 Activity

Activity

0% Hemolysis
Toxicity
6.25 µM
Hemolytic Cytotoxic
0% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fungicidal effect of piscidin on Candida albicans: pore formation in lipid vesicles and activity in fungal membranes. | Biol Pharm Bull | 2008
Evidence 31 Activity

Activity

4% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
4% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fungicidal effect of piscidin on Candida albicans: pore formation in lipid vesicles and activity in fungal membranes. | Biol Pharm Bull | 2008
Evidence 32 Activity

Activity

25% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
25% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Fungicidal effect of piscidin on Candida albicans: pore formation in lipid vesicles and activity in fungal membranes. | Biol Pharm Bull | 2008
Evidence 33 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.11713517]5% hemolytic activity at 100 µg/mL against human erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Nature. 2001 Nov 15 414(6861):268-269.
Evidence 34 Hemolysis

Activity

5 %
% Hemolysis
[Ref.11713517]5% hemolytic activity at 100 µg/mL against human erythrocytes
Hemolysis

Target

human erythrocytes

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Nature. 2001 Nov 15 414(6861):268-269.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.