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Peptide record

TPDB10033

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB10033
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP dbAMP 3.0 i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GMATKAGTAFGKAAKAIIGAAL
Physicochemical Analysis
C90H155N25O25S1
RNDCEQHPSWYV
A
2019.43
10.84
3
0
13
+3
-0.61
0.782
89.55
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
8
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
2
I
1
L
3
K
1
M
1
F
0
P
0
S
2
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 8 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 1 K: 3 M: 1 F: 1 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C90H155N25O25S1
2019.43
10.84
+3
-0.61
0.782
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
16 µM

Target

Escherichia coli

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. c
Evidence 2 Activity

Activity

MIC
Antibacterial
128 µM

Target

P.aeruginosa

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and
Evidence 3 Activity

Activity

MIC
Antibacterial
>256 µM

Target

S.aureus

Source & Reference

dbAMP

Other

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

M. luteus

Source & Reference

dbAMP

Other

gainst Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32 uM).
Evidence 5 Activity

Activity

MIC
Antibacterial
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP

Other

uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32 uM).
Evidence 6 Activity

Activity

MIC
Antifungal
16 µM

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. c
Evidence 7 Activity

Activity

MIC
Antifungal
128 µM

Target

P.aeruginosa

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and
Evidence 8 Activity

Activity

MIC
Antifungal
>256 µM

Target

S.aureus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32
Evidence 9 Activity

Activity

MIC
Antifungal
2 µM

Target

M. luteus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

gainst Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32 uM).
Evidence 10 Activity

Activity

MIC
Antifungal
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP CAFPdb Antifungipept

Other

uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32 uM).
Evidence 11 Activity

Activity

MIC
Antiparasitic
16 µM

Target

Escherichia coli

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. c
Evidence 12 Activity

Activity

MIC
Antiparasitic
128 µM

Target

P.aeruginosa

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and
Evidence 13 Activity

Activity

MIC
Antiparasitic
>256 µM

Target

S.aureus

Source & Reference

dbAMP 3.0

Other

Active against Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32
Evidence 14 Activity

Activity

MIC
Antiparasitic
2 µM

Target

M. luteus

Source & Reference

dbAMP 3.0

Other

gainst Gram- E. coli (MIC 16 uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
64 µM

Target

S. cerevisiae

Source & Reference

dbAMP 3.0

Other

uM), P.aeruginosa (MIC 128 uM), Gram+ S.aureus (MIC >256uM), M. luteus (MIC 2 uM), yeast S. cerevisiae (MIC 64 uM), and parasite T. brucei (LC9516-32 uM).
Evidence 16 Activity

Activity

50% Hemolysis
Toxicity
>256 µM
Hemolytic Cytotoxic
50% Hemolysis | >256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 17 Activity

Activity

IC50
Toxicity
64 µM
Cytotoxic
IC50 | 64 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Origin and functional diversification of an amphibian defense peptide arsenal. | PLoS Genet | 2013
Evidence 18 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.