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Peptide record

TPDB10020

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB10020
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
MQFITDLIKKAVDFFKGLFGNK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C122H190N28O30S1
RCEHPSWY
KF
2561.08
10.16
4
2
11
+2
0.58
0.209
88.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
2
D
0
C
0
E
1
Q
2
G
0
H
2
I
2
L
4
K
1
M
4
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 2 K: 4 M: 1 F: 4 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
22 reviewed residue count
C122H190N28O30S1 sequence-only estimate (linear, free termini)
2561.08 sequence-only estimate (linear, free termini)
10.16 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.58 sequence-only estimate (linear, free termini)
0.209 sequence-only estimate (linear, free termini)
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

L. pneumophila Lens

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
eumophila ATCC 33216 (sg5), and L. pneumophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid
Evidence 2 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

umophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid composition. Cells in stationary
Evidence 3 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

L. pneumophila Lens

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
eumophila ATCC 33216 (sg5), and L. pneumophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid
Evidence 4 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP Antifungipept

Other

umophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid composition. Cells in stationary
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
3 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri. | Peptides | 2008
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
2.78 µM
Hemolytic Cytotoxic
10% Hemolysis | 2.78 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging. | PLoS One | 2016
Evidence 7 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.