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Peptide record

TPDB10020

Antibacterial Anticancer Antifungal Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB10020
Antibacterial Anticancer Antifungal Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
MQFITDLIKKAVDFFKGLFGNK
Physicochemical Analysis
C122H190N28O30S1
RCEHPSWY
KF
2561.08
10.16
4
2
11
+2
0.99
0.209
88.64
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
2
D
0
C
0
E
1
Q
2
G
0
H
2
I
2
L
4
K
1
M
4
F
0
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 2 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 2 L: 2 K: 4 M: 1 F: 4 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C122H190N28O30S1
2561.08
10.16
+2
0.99
0.209
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

L. pneumophila Lens

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
eumophila ATCC 33216 (sg5), and L. pneumophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid
Evidence 2 Activity

Activity

MIC
Antibacterial
12 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP

Other

umophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid composition. Cells in stationary
Evidence 3 Activity

Activity

MIC
Antifungal
3 µg/mL

Target

L. pneumophila Lens

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
eumophila ATCC 33216 (sg5), and L. pneumophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid
Evidence 4 Activity

Activity

MIC
Antifungal
12 µg/mL

Target

B. megaterium

Source & Reference

dbAMP DRAMP Antifungipept

Other

umophila ATCC 33215 (sg6). In addition, MIC assays: L. pneumophila Lens (MIC 3 ug/ml) and B. megaterium (MIC 12 ug/ml). Its anti-Legionella activity is modulated by fatty acid composition. Cells in stationary
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
3 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 3 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Characterization of anti-Legionella activity of warnericin RK and delta-lysin I from Staphylococcus warneri. | Peptides | 2008
Evidence 6 Activity

Activity

10% Hemolysis
Toxicity
2.78 µM
Hemolytic Cytotoxic
10% Hemolysis | 2.78 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Specific Anti-Leukemic Activity of the Peptide Warnericin RK and Analogues and Visualization of Their Effect on Cancer Cells by Chemical Raman Imaging. | PLoS One | 2016
Evidence 7 Hemolysis

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.