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Peptide record

TPDB10016

TAT-Ras-GAP317-326 Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB10016
TAT-Ras-GAP317-326
Antibacterial Anticancer Antifungal Antiparasitic Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
AntiBP3 Peptipedia ACP740 _ACP240 AntiCP 2.0 CancerPPD 2.0 SATPdb dbACP iACP-DRLF pep-lab Antifungipept CAFPdb dbAMP CPPsite3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, ACP740 _ACP240, and other sources, with an available 3D structural model.
Sequence
GRKKRRQRRRGGWMWVTNLRTD
Physicochemical Analysis
C119H201N49O29S1
ACEHIFPSY
R
2814.28
12.80
9
1
5
+8
5.77
-2.014
30.91
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
390.86
4
Residue Composition
number
0
A
7
R
1
N
1
D
0
C
0
E
1
Q
3
G
0
H
0
I
1
L
2
K
1
M
0
F
0
P
0
S
2
T
2
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 7 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 3 H: 0 I: 0 L: 1 K: 2 M: 1 F: 0 P: 0 S: 0 T: 2 W: 2 Y: 0 V: 1
Chemical Descriptors
22
C119H201N49O29S1
2814.28
12.80
+8
5.77
-2.014
Free
L
Linear
Free
Anticancer
Not Available
Evidence Records 5 records
Evidence 1 Activity

Activity

15% apoptosis at 10 µM
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

LDH leakage assay
16 to 24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004

Other

Source Activity Label Source Definition
Anticancer
CancerPPD 2.0 manually curated experimentally verified anticancer peptide/protein annotation.
Evidence 2 Activity

Activity

47% apoptosis at 20 µM
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

LDH leakage assay
16 to 24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004
Evidence 3 Activity

Activity

72% apoptosis at 30 µM
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

LDH leakage assay
16 to 24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004
Evidence 4 Activity

Activity

79% apoptosis at 50 µM
Anticancer

Target

Cervical Cancer
HeLa
Cervix

Assay & Model

LDH leakage assay
16 to 24-h

Source & Reference

CancerPPD 2.0 dbACP SATPdb
CancerPPD2
2004
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Oncogene. 2004 Nov 25 23(55):8971-8.