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Peptide record

TPDB10014

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB10014
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP dbAMP 3.0 APD_complete PD_Hemolysis
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
FFRHIKSFWKGAKAIFRGARQG
Physicochemical Analysis
C124H186N38O25
NDCELMPTYV
F
2609.08
12.71
7
0
10
+6
-0.40
-0.418
49.09
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
5500
210.80
2
Residue Composition
number
3
A
3
R
0
N
0
D
0
C
0
E
1
Q
3
G
1
H
2
I
0
L
3
K
0
M
4
F
0
P
1
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 3 H: 1 I: 2 L: 0 K: 3 M: 0 F: 4 P: 0 S: 1 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
22
C124H186N38O25
2609.08
12.71
+6
-0.40
-0.418
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
15-20 µM

Target

V. parahaemolyticus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus (MIC 15-20 uM), and P. pastoris (MIC 1.25 uM). Upregulated after V. Parahaemolyticus challenge. Upregula
Evidence 2 Activity

Activity

MIC
Antibacterial
1.25 µM

Target

P. pastoris

Source & Reference

dbAMP

Other

Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus (MIC 15-20 uM), and P. pastoris (MIC 1.25 uM). Upregulated after V. Parahaemolyticus challenge. Upregulated after V. Parahaemolyticus c
Evidence 3 Activity

Activity

MIC
Antifungal
15-20 µM

Target

V. parahaemolyticus

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus (MIC 15-20 uM), and P. pastoris (MIC 1.25 uM). Upregulated after V. Parahaemolyticus challenge. Upregula
Evidence 4 Activity

Activity

MIC
Antifungal
1.25 µM

Target

P. pastoris

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus (MIC 15-20 uM), and P. pastoris (MIC 1.25 uM). Upregulated after V. Parahaemolyticus challenge. Upregulated after V. Parahaemolyticus c
Evidence 5 Activity

Activity

MIC
Antiparasitic
15-20 µM

Target

V. parahaemolyticus

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus (MIC 15-20 uM), and P. pastoris (MIC 1.25 uM). Upregulated after V. Parahaemolyticus challenge. Upregula
Evidence 6 Activity

Activity

MIC
Antiparasitic
1.25 µM

Target

P. pastoris

Source & Reference

dbAMP 3.0

Other

Active against E. coli, S. aureus (MIC 10-20), V. parahaemolyticus (MIC 15-20 uM), and P. pastoris (MIC 1.25 uM). Upregulated after V. Parahaemolyticus challenge. Upregulated after V. Parahaemolyticus c
Evidence 7 Activity

Activity

0.16±0.05% Hemolysis
Toxicity
2.5 µM
Hemolytic Cytotoxic
0.16±0.05% Hemolysis | 2.5 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017
Evidence 8 Activity

Activity

2.07±0.14% Hemolysis
Toxicity
5 µM
Hemolytic Cytotoxic
2.07±0.14% Hemolysis | 5 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017
Evidence 9 Activity

Activity

9.63±1.50% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
9.63±1.50% Hemolysis | 10 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017
Evidence 10 Activity

Activity

17.56±0.95% Hemolysis
Toxicity
20 µM
Hemolytic Cytotoxic
17.56±0.95% Hemolysis | 20 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Three new piscidins from orange-spotted grouper (Epinephelus coioides): Phylogeny, expression and functional characterization. | Fish Shellfish Immunol | 2017
Evidence 11 Hemolysis

Source & Reference

APD_complete PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.