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Peptide record

TPDB09993

Antibacterial Anticancer Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09993
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia AFP-GFuse Antifungipept CAFPdb dbAMP ToxinPred 3.0
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, AFP-GFuse, and other sources, with an available 3D structural model.
Sequence
TRRKFWKKVLNGALKIAPFLLG
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C123H202N34O25
DCEQHMSY
LK
2557.17
12.44
6
0
11
+6
0.86
0.045
110.91
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
5500
2.15
2
Residue Composition
number
2
A
2
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
4
L
4
K
0
M
2
F
1
P
0
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 4 M: 0 F: 2 P: 1 S: 0 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
22 reviewed residue count
C123H202N34O25 sequence-only estimate (linear, free termini)
2557.17 sequence-only estimate (linear, free termini)
12.44 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
0.86 sequence-only estimate (linear, free termini)
0.045 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against Gram- bacteria E. coli, S. dysenteriae, K. pneumoniae, K. oxytoca, P. mirabilis, A. baumannii, S. maltophilia, and P. aeruginosa, Gram+ bacteria S. aureus, B. cereus, E. faecium, and S. epidermidis, and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. harveyi, V. parahaemdyticus, V. anguillarum, and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml, it showed only 47% hemolysis (human red blood cells).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against Gram- bacteria E. coli, S. dysenteriae, K. pneumoniae, K. oxytoca, P. mirabilis, A. baumannii, S. maltophilia, and P. aeruginosa, Gram+ bacteria S. aureus, B. cereus, E. faecium, and S. epidermidis, and fungi C. albicans. Also active against aquatic pathogenic bacteria A. sobria, A. hydrophila, A. veronii, V. harveyi, V. parahaemdyticus, V. anguillarum, and V. cholerae. Antibacterial activity appears to be salt-resistant (salt-insensitive). At a high concentration of 200 ug/ml, it showed only 47% hemolysis (human red blood cells).
Evidence 3 Activity

Activity

89±0.6% Cell death
Toxicity
200 µg/mL
Cytotoxic
89±0.6% Cell death | 200 | µg/mL | target cell: Chinese hamster ovary cells CHO

Target

Chinese hamster ovary cells CHO

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 4 Activity

Activity

42±4.1% Cell death
Toxicity
200 µg/mL
Cytotoxic
42±4.1% Cell death | 200 | µg/mL | target cell: Murine peritoneal macrophages

Target

Murine peritoneal macrophages

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017
Evidence 5 Activity

Activity

47±3.5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
47±3.5% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
As-CATH1-6, novel cathelicidins with potent antimicrobial and immunomodulatory properties from Alligator sinensis, play pivotal roles in host antimicrobial immune responses. | Biochem J | 2017