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Peptide record

TPDB09987

Antibacterial Antifungal Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09987
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb dbAMP PD_Hemolysis ToxinPred 3.0
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, CAFPdb, and other sources, with an available 3D structural model.
Sequence
FFGSTIGALANFLPSLISKIRN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C111H176N28O29
DCEQHMWYV
ILFS
2366.79
11.49
2
0
11
+2
0.12
0.727
115.45
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
6
Residue Composition
number
2
A
1
R
2
N
0
D
0
C
0
E
0
Q
2
G
0
H
3
I
3
L
1
K
0
M
3
F
1
P
3
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 1 M: 0 F: 3 P: 1 S: 3 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
22 reviewed residue count
C111H176N28O29 sequence-only estimate (linear, free termini)
2366.79 sequence-only estimate (linear, free termini)
11.49 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.12 sequence-only estimate (linear, free termini)
0.727 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

13.1% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
13.1% Hemolysis | 32 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Molecular Cloning and Functional Characterization of Antimicrobial Peptides Brevinin-1ULf and Ulmin-1ULa in the Skin of the Newly Classified Ryukyu Brown Frog Rana ulma. | Zoolog Sci | 2017
Evidence 2 Activity

Activity

54.7% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
54.7% Hemolysis | 64 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Molecular Cloning and Functional Characterization of Antimicrobial Peptides Brevinin-1ULf and Ulmin-1ULa in the Skin of the Newly Classified Ryukyu Brown Frog Rana ulma. | Zoolog Sci | 2017
Evidence 3 Activity

Activity

90.1% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
90.1% Hemolysis | 128 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Molecular Cloning and Functional Characterization of Antimicrobial Peptides Brevinin-1ULf and Ulmin-1ULa in the Skin of the Newly Classified Ryukyu Brown Frog Rana ulma. | Zoolog Sci | 2017
Evidence 4 Activity

Activity

87% Killing
Toxicity
32 µg/mL
Cytotoxic
87% Killing | 32 | µg/mL | target cell: Monkey COS-7 cells

Target

Monkey COS-7 cells

Source & Reference

NA
DBAASP
Molecular Cloning and Functional Characterization of Antimicrobial Peptides Brevinin-1ULf and Ulmin-1ULa in the Skin of the Newly Classified Ryukyu Brown Frog Rana ulma. | Zoolog Sci | 2017
Evidence 5 Activity

Activity

100% Killing
Toxicity
64 µg/mL
Cytotoxic
100% Killing | 64 | µg/mL | target cell: Monkey COS-7 cells

Target

Monkey COS-7 cells

Source & Reference

NA
DBAASP
Molecular Cloning and Functional Characterization of Antimicrobial Peptides Brevinin-1ULf and Ulmin-1ULa in the Skin of the Newly Classified Ryukyu Brown Frog Rana ulma. | Zoolog Sci | 2017
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis