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Peptide record

TPDB09981

Antibacterial Anticancer Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09981
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia CAFPdb
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, and CAFPdb, with an available 3D structural model.
Sequence
KGIRGYKGGYCKGAFKQTCKCY
Physicochemical Analysis
C109H171N31O28S3
NDEHLMPSWV
GK
2459.93
9.96
6
0
6
+6
1.38
-0.795
22.27
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
4595
186.79
8
Residue Composition
number
1
A
1
R
0
N
0
D
3
C
0
E
1
Q
5
G
0
H
1
I
0
L
5
K
0
M
1
F
0
P
0
S
1
T
0
W
3
Y
0
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 0 C: 3 E: 0 Q: 1 G: 5 H: 0 I: 1 L: 0 K: 5 M: 0 F: 1 P: 0 S: 0 T: 1 W: 0 Y: 3 V: 0
Chemical Descriptors
22
C109H171N31O28S3
2459.93
9.96
+6
1.38
-0.795
Evidence Records 6 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 2 Activity

Activity

30% Cytotoxicity
Toxicity
256 µg/mL
Cytotoxic
30% Cytotoxicity | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Mouse Embryonic Fibroblasts (MEF)

Target

Mouse Embryonic Fibroblasts (MEF)

Source & Reference

NA
DBAASP
Structural and functional characterization of peptides derived from the carboxy-terminal region of a defensin from the tick Ornithodoros savignyi. | J Pept Sci | 2013
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
0% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 5 Activity

Activity

10% Cytotoxicity
Toxicity
256 µg/mL
Cytotoxic
10% Cytotoxicity | 256 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity. | ACS Omega | 2024
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Pept Sci. 2022 May 28(5):e3383.