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Peptide record

TPDB09970

Antibacterial Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09970
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
GFLLKLKLGAKLFASAFVNSIK
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C115H189N27O26
RDCEQHMPTWY
L
2365.93
11.00
4
0
13
+4
-0.64
0.909
133.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
3
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
5
L
4
K
0
M
3
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 3 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 5 K: 4 M: 0 F: 3 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22 reviewed residue count
C115H189N27O26 sequence-only estimate (linear, free termini)
2365.93 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
-0.64 sequence-only estimate (linear, free termini)
0.909 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 32 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Combined Molecular Cloning and Mass Spectrometric Method to Identify, Characterize, and Design Frenatin Peptides from the Skin Secretion of Litoria infrafrenata. | Molecules | 2016
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
25% Hemolysis | 128 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Combined Molecular Cloning and Mass Spectrometric Method to Identify, Characterize, and Design Frenatin Peptides from the Skin Secretion of Litoria infrafrenata. | Molecules | 2016
Evidence 3 Activity

Activity

48% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
48% Hemolysis | 512 | µg/mL | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
A Combined Molecular Cloning and Mass Spectrometric Method to Identify, Characterize, and Design Frenatin Peptides from the Skin Secretion of Litoria infrafrenata. | Molecules | 2016