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Peptide record

TPDB09967

Antibacterial Antifungal Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09967
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LHRLVKLVAALLRGYASKVDTH
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C112H190N34O28
NCEQIMFPW
L
2460.95
10.71
6
1
12
+3
1.00
0.323
141.82
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
1490
0.61
3
Residue Composition
number
3
A
2
R
0
N
1
D
0
C
0
E
0
Q
1
G
2
H
0
I
5
L
2
K
0
M
0
F
0
P
1
S
1
T
0
W
1
Y
3
V
Amino Acid Distribution
A: 3 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 5 K: 2 M: 0 F: 0 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 3
Chemical Descriptors
22 reviewed residue count
C112H190N34O28 sequence-only estimate (linear, free termini)
2460.95 sequence-only estimate (linear, free termini)
10.71 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
1.00 sequence-only estimate (linear, free termini)
0.323 sequence-only estimate (linear, free termini)
Evidence Records 6 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
1-8 µM
Hemolytic Cytotoxic
0% Hemolysis | 1-8 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 2 Activity

Activity

2.00±1.13% Hemolysis
Toxicity
16 µM
Hemolytic Cytotoxic
2.00±1.13% Hemolysis | 16 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 3 Activity

Activity

15.47±1.58% Hemolysis
Toxicity
32 µM
Hemolytic Cytotoxic
15.47±1.58% Hemolysis | 32 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 4 Activity

Activity

28.81±2.67% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
28.81±2.67% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 5 Activity

Activity

44.15±5.64% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
44.15±5.64% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Encrypted Antimicrobial Peptides from Plant Proteins. | Sci Rep | 2017
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis