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Peptide record

TPDB09964

Antibacterial Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09964
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KWKLFKKIFKRIVQRIKDFLRN
Physicochemical Analysis
C140H230N40O27
ACEGHMPSTY
K
2905.62
12.18
9
1
10
+8
3.38
-0.664
101.82
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
189.29
2
Residue Composition
number
0
A
3
R
1
N
1
D
0
C
0
E
1
Q
0
G
0
H
3
I
2
L
6
K
0
M
3
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 1 D: 1 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 3 L: 2 K: 6 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C140H230N40O27
2905.62
12.18
+8
3.38
-0.664
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
221±3.27 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 221±3.27 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Novel Hybrid Peptide Cecropin A (1-8)-LL37 (17-30) with Potential Antibacterial Activity. | Int J Mol Sci | 2016
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic
Hemolytic_activity: [Ref.29925795] 50% hemolysis at 221 ± 3.45µg/ml against sheep red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2018 Jun 20 23(6). pii: E1491.
Evidence 3 Activity

Activity

HC50
Toxicity
219
Hemolytic
Hemolytic_activity: [Ref.29920061]HC50 =219 ± 2.98µg/mL against sheep erythrocyte cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Molecules. 2018 Jun 20 23(6). pii: E1491.