Back to search

Peptide record

TPDB09963

Antibacterial Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09963
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KTRNWFSEHFKKVKEKLKDTFA
Physicochemical Analysis
C129H199N35O33
CQGIMPY
K
2768.21
10.53
8
3
7
+4
7.91
-1.364
35.45
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
5500
198.68
4
Residue Composition
number
1
A
1
R
1
N
1
D
0
C
2
E
0
Q
0
G
1
H
0
I
1
L
6
K
0
M
3
F
0
P
1
S
2
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 1 D: 1 C: 0 E: 2 Q: 0 G: 0 H: 1 I: 0 L: 1 K: 6 M: 0 F: 3 P: 0 S: 1 T: 2 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C129H199N35O33
2768.21
10.53
+4
7.91
-1.364
Evidence Records 2 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Peptides from American alligator plasma are antimicrobial against multi-drug resistant bacterial pathogens including Acinetobacter baumannii. | BMC Microbiol | 2016
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.27542832] Not hemolytic to sheep red blood cells. | Cytotoxicity: [Ref.27542832] The cell proliferation of A549 human lung epithelial cells is 190%, 167%, 150%, 135% and 144% at peptide concentrations of 1 µg/ml, 10 µg/ml, 25 µg/ml, 50 µg/ml, 100 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
BMC Microbiol. 2016 Aug 19 16(1):189.