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Peptide record

TPDB09952

Antibacterial Antifungal Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09952
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
SCLPKEEQIGKSTRGRKCRRKK
Physicochemical Analysis
C106H194N40O31S2
ANDHMFWYV
K
2589.08
11.04
9
2
2
+7
12.33
-1.791
35.45
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
4.83
6
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
2
E
1
Q
2
G
0
H
1
I
1
L
5
K
0
M
0
F
1
P
2
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 2 Q: 1 G: 2 H: 0 I: 1 L: 1 K: 5 M: 0 F: 0 P: 1 S: 2 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C106H194N40O31S2
2589.08
11.04
+7
12.33
-1.791
Evidence Records 6 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
active against E. coli (LC 16 uM). LC=lethal concentration.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

dbAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
active against E. coli (LC 16 uM). LC=lethal concentration.
Evidence 3 Activity

Activity

45% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
45% Hemolysis | 12.5 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 4 Activity

Activity

60% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
60% Hemolysis | 25 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Effects of increasing hydrophobicity by N-terminal myristoylation on the antibacterial and hemolytic activities of the C-terminal cationic segments of human-?-defensins 1-3. | Chem Biol Drug Des | 2018
Evidence 6 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis