Back to search

Peptide record

TPDB09948

Antibacterial Antifungal Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09948
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP PD_Hemolysis
standard
No
A 22-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RCPGRTRQIGTIFGPRIKCRSW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C112H186N40O27S2
ANDEHLMYV
R
2589.08
12.23
6
0
5
+6
3.13
-0.732
53.18
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5625
2.17
6
Residue Composition
number
0
A
5
R
0
N
0
D
2
C
0
E
1
Q
3
G
0
H
3
I
0
L
1
K
0
M
1
F
2
P
1
S
2
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 3 H: 0 I: 3 L: 0 K: 1 M: 0 F: 1 P: 2 S: 1 T: 2 W: 1 Y: 0 V: 0
Chemical Descriptors
22 reviewed residue count
C112H186N40O27S2 sequence-only estimate (linear, free termini)
2589.08 sequence-only estimate (linear, free termini)
12.23 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
3.13 sequence-only estimate (linear, free termini)
-0.732 sequence-only estimate (linear, free termini)
Evidence Records 3 records
Evidence 1 Activity

Activity

80% Hemolysis
Toxicity
3 µM
Hemolytic Cytotoxic
80% Hemolysis | 3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal fatty acylation of peptides spanning the cationic C-terminal segment of bovine ?-defensin-2 results in salt-resistant antibacterial activity. | Biophys Chem | 2015
Evidence 2 Activity

Activity

25% Hemolysis
Toxicity
3 µM
Hemolytic Cytotoxic
25% Hemolysis | 3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
N-terminal fatty acylation of peptides spanning the cationic C-terminal segment of bovine ?-defensin-2 results in salt-resistant antibacterial activity. | Biophys Chem | 2015
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis