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Peptide record

TPDB09943

Antibacterial Antifungal Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09943
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RRLRPRRPRLPRPRPRPRPRPR
Physicochemical Analysis
C124H224N58O23
ANDCEQGHIKMFSTWYV
R
2895.52
13.44
12
0
2
+12
12.20
-2.691
35.45
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
12
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
2
L
0
K
0
M
0
F
8
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 12 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 0 M: 0 F: 0 P: 8 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
22
C124H224N58O23
2895.52
13.44
+12
12.20
-2.691
Evidence Records 16 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

p. clinical isolate

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
p, or M17 (MIC1-2 uM), P. aeruginosa ATCC 27853, clincla strains (MIC 2 uM), Klebsiella spp. clinical isolate (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP
Evidence 2 Activity

Activity

MIC
Antibacterial
2 µM

Target

A. baumannii clinical isolate

Source & Reference

dbAMP DRAMP

Other

nosa ATCC 27853, clincla strains (MIC 2 uM), Klebsiella spp. clinical isolate (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 7
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µM

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

), Klebsiella spp. clinical isolate (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-inte
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µM

Target

M. luteus CIP A270

Source & Reference

dbAMP DRAMP

Other

te (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-intermedius clin. isolate (MIC >64
Evidence 5 Activity

Activity

MIC
Antibacterial
>64 µM

Target

n. isolate

Source & Reference

dbAMP DRAMP

Other

CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-intermedius clin. isolate (MIC >64 uM), C. albicans 820 (MIC 64 uM), and C-parapsilosis (MIC > 64 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
64 µM

Target

Candida albicans 820

Source & Reference

dbAMP DRAMP

Other

ureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-intermedius clin. isolate (MIC >64 uM), C. albicans 820 (MIC 64 uM), and C-parapsilosis (MIC > 64 uM).
Evidence 7 Activity

Activity

MIC
Antifungal
4 µM

Target

p. clinical isolate

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
p, or M17 (MIC1-2 uM), P. aeruginosa ATCC 27853, clincla strains (MIC 2 uM), Klebsiella spp. clinical isolate (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP
Evidence 8 Activity

Activity

MIC
Antifungal
2 µM

Target

A. baumannii clinical isolate

Source & Reference

dbAMP DRAMP CAFPdb

Other

nosa ATCC 27853, clincla strains (MIC 2 uM), Klebsiella spp. clinical isolate (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 7
Evidence 9 Activity

Activity

MIC
Antifungal
2 µM

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP CAFPdb

Other

), Klebsiella spp. clinical isolate (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-inte
Evidence 10 Activity

Activity

MIC
Antifungal
1 µM

Target

M. luteus CIP A270

Source & Reference

dbAMP DRAMP CAFPdb

Other

te (MIC 4 uM), A. baumannii clinical isolate (MIC 2 uM), L. monocytogenes EGD (MIC 2 uM), M. luteus CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-intermedius clin. isolate (MIC >64
Evidence 11 Activity

Activity

MIC
Antifungal
>64 µM

Target

n. isolate

Source & Reference

dbAMP DRAMP CAFPdb

Other

CIP A270 (MIC 1 uM), S-aureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-intermedius clin. isolate (MIC >64 uM), C. albicans 820 (MIC 64 uM), and C-parapsilosis (MIC > 64 uM).
Evidence 12 Activity

Activity

MIC
Antifungal
64 µM

Target

Candida albicans 820

Source & Reference

dbAMP DRAMP CAFPdb

Other

ureus ATCC 25923 or 710A or MRSA (MIC > 64 uM), S-intermedius clin. isolate (MIC >64 uM), C. albicans 820 (MIC 64 uM), and C-parapsilosis (MIC > 64 uM).
Evidence 13 Activity

Activity

2% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
2% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. | Front Microbiol | 2018
Evidence 14 Activity

Activity

IC50
Toxicity
>25 µM
Cytotoxic
IC50 | >25 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. | Front Microbiol | 2018
Evidence 15 Activity

Activity

IC50
Toxicity
>25 µM
Cytotoxic
IC50 | >25 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Combined Antibacterial Effects of Goat Cathelicidins With Different Mechanisms of Action. | Front Microbiol | 2018
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.27818338] No hemolytic activity

Target

erythrocytes

Source & Reference

NA
DRAMP
Acta Naturae. 2016 Jul-Sep 8(3):136-146.