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Peptide record

TPDB09928

Antibacterial Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09928
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP Peptipedia HemoPI Hemolytic2
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFFALIPKIISSPLFKTLLSAV
Physicochemical Analysis
C117H188N24O27
RNDCEQHMWY
L
2362.92
10.60
2
0
13
+2
-3.41
1.382
146.36
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
4
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
3
I
4
L
2
K
0
M
3
F
2
P
3
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 3 L: 4 K: 2 M: 0 F: 3 P: 2 S: 3 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C117H188N24O27
2362.92
10.60
+2
-3.41
1.382
Evidence Records 4 records
Evidence 1 Activity

Activity

28% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
28% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A comparative study on the structure and function of a cytolytic alpha-helical peptide and its antimicrobial beta-sheet diastereomer. | Eur J Biochem | 1999
Evidence 2 Activity

Activity

55% Killing
Toxicity
15.6 µg/mL
Cytotoxic
55% Killing | 15.6 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens. | Eur J Med Chem | 2022
Evidence 3 Activity

Activity

88% Killing
Toxicity
31.25 µg/mL
Cytotoxic
88% Killing | 31.25 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Systematic comparison of activity and mechanism of antimicrobial peptides against nosocomial pathogens. | Eur J Med Chem | 2022
Evidence 4 Hemolysis

Source & Reference

HemoPI
NA