TPDB

3D PDB MODEL

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TPDB ID TPDB09926

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

AntiBP3 dbAMP Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 22-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from AntiBP3, dbAMP, Peptipedia, and other sources, with an available 3D structural model.

Sequence

GLFLDTLKKFAKAGMEAVINPK

FASTA

>TPDB09926|Antibacterial;Antifungal|length=22
GLFLDTLKKFAKAGMEAVINPK

Formula C111H183N27O29S1

Absent Amino Acids RCQHSWY

Common Amino Acids K

Mass 2391.90

PI 10.16

Basic Residues 4

Acidic Residues 2

Hydrophobic Residues 11

Net Charge +2

Boman Index 3.32

Hydrophobicity 0.173

Aliphatic Index 97.73

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 2

number

3

A

0

R

1

N

1

D

0

C

1

E

0

Q

2

G

0

H

1

I

3

L

4

K

1

M

2

F

1

P

0

S

1

T

0

W

0

Y

1

V

Amino Acid Distribution

A: 3 R: 0 N: 1 D: 1 C: 0 E: 1 Q: 0 G: 2 H: 0 I: 1 L: 3 K: 4 M: 1 F: 2 P: 1 S: 0 T: 1 W: 0 Y: 0 V: 1

Length

22

Formula

C111H183N27O29S1

Mass

2391.90

PI

10.16

Net Charge

+2

Boman Index

3.32

Hydrophobicity

0.173

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 80 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

weakly active against S. aureus (MIC 80 uM) and E. coli (MIC 80 uM). UPdated 7/2021

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 80 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Evidence Text

weakly active against S. aureus (MIC 80 uM) and E. coli (MIC 80 uM). UPdated 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 80 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

weakly active against S. aureus (MIC 80 uM) and E. coli (MIC 80 uM). UPdated 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 80 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP Antifungipept

Other

Evidence Text

weakly active against S. aureus (MIC 80 uM) and E. coli (MIC 80 uM). UPdated 7/2021