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Peptide record

TPDB09911

Antibacterial Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09911
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
FFHHIFRGIVHVGKTVHRLVTG
Physicochemical Analysis
C121H185N37O25
ANDCEQMPSWY
HV
2558.03
12.41
7
0
10
+3
2.47
0.441
105.91
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
3
G
4
H
2
I
1
L
1
K
0
M
3
F
0
P
0
S
2
T
0
W
0
Y
4
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 4 I: 2 L: 1 K: 1 M: 0 F: 3 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 4
Chemical Descriptors
22
C121H185N37O25
2558.03
12.41
+3
2.47
0.441
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
40 µM
Hemolytic Cytotoxic
50% Hemolysis | 40 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Single amino acid substitutions at specific positions of the heptad repeat sequence of piscidin-1 yielded novel analogs that show low cytotoxicity as well as in vitro and in vivo anti-endotoxin activity. | Antimicrob Agents Chemother | 2016