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Peptide record

TPDB09910

Antibacterial Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09910
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and PD_Hemolysis, with an available 3D structural model.
Sequence
FFHHIFRGIVHVGKTAHRLVTG
Physicochemical Analysis
C119H181N37O25
NDCEQMPSWY
H
2529.98
12.41
7
0
10
+3
2.23
0.332
97.27
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
2
Residue Composition
number
1
A
2
R
0
N
0
D
0
C
0
E
0
Q
3
G
4
H
2
I
1
L
1
K
0
M
3
F
0
P
0
S
2
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 1 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 4 I: 2 L: 1 K: 1 M: 0 F: 3 P: 0 S: 0 T: 2 W: 0 Y: 0 V: 3
Chemical Descriptors
22
C119H181N37O25
2529.98
12.41
+3
2.23
0.332
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
50% Hemolysis | 500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Single amino acid substitutions at specific positions of the heptad repeat sequence of piscidin-1 yielded novel analogs that show low cytotoxicity as well as in vitro and in vivo anti-endotoxin activity. | Antimicrob Agents Chemother | 2016
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
12.5 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 12.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Substitution of lysine for isoleucine at the center of the nonpolar face of the antimicrobial peptide, piscidin-1, leads to an increase in the rapidity of bactericidal activity and a reduction in toxicity. | Infect Drug Resist | 2019
Evidence 3 Activity

Activity

100% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
100% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Substitution of lysine for isoleucine at the center of the nonpolar face of the antimicrobial peptide, piscidin-1, leads to an increase in the rapidity of bactericidal activity and a reduction in toxicity. | Infect Drug Resist | 2019
Evidence 4 Activity

Activity

>90% Killing
Toxicity
50 µg/mL
Cytotoxic
>90% Killing | 50 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Substitution of lysine for isoleucine at the center of the nonpolar face of the antimicrobial peptide, piscidin-1, leads to an increase in the rapidity of bactericidal activity and a reduction in toxicity. | Infect Drug Resist | 2019
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis