Back to search

Peptide record

TPDB09903

Antibacterial Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09903
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 22-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
HRVKRNGFRKFMRRLKKFFAGG
Physicochemical Analysis
C125H202N44O24S1
DCEQIPSTWY
R
2737.32
13.01
10
0
8
+9
4.01
-1.050
35.45
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
5
R
1
N
0
D
0
C
0
E
0
Q
3
G
1
H
0
I
1
L
4
K
1
M
4
F
0
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 5 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 3 H: 1 I: 0 L: 1 K: 4 M: 1 F: 4 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
22
C125H202N44O24S1
2737.32
13.01
+9
4.01
-1.050
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- E. coli ATCC 25922 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), Gram+ S
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µg/mL

Target

Pseudomonas aeruginosa ATCC 27853

Source & Reference

dbAMP DRAMP

Other

Active against Gram- E. coli ATCC 25922 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B.
Evidence 3 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium ATCC 14028

Source & Reference

dbAMP DRAMP

Other

e against Gram- E. coli ATCC 25922 (MIC 3 ug/ml), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus ATCC 10876 (MIC 32 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

S.aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

), P. aeruginosa ATCC 27853 (MIC 8 ug/ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus ATCC 10876 (MIC 32 ug/ml).
Evidence 5 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

B. cereus ATCC 10876

Source & Reference

dbAMP DRAMP

Other

ml), S. typhimurium ATCC 14028 (MIC 2 ug/ml), Gram+ S.aureus ATCC 29213 (MIC >128 ug/ml), B. cereus ATCC 10876 (MIC 32 ug/ml).
Evidence 6 Activity

Activity

0% Hemolysis
Toxicity
8 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 8 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 7 Activity

Activity

1.7±0.5% Hemolysis
Toxicity
16 µg/mL
Hemolytic Cytotoxic
1.7±0.5% Hemolysis | 16 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 8 Activity

Activity

3.1±0.5% Hemolysis
Toxicity
32 µg/mL
Hemolytic Cytotoxic
3.1±0.5% Hemolysis | 32 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 9 Activity

Activity

4.0±0.2% Hemolysis
Toxicity
64 µg/mL
Hemolytic Cytotoxic
4.0±0.2% Hemolysis | 64 | µg/mL | target cell: Chicken erythrocytes

Target

Chicken erythrocytes

Source & Reference

NA
DBAASP
Genomewide Analysis of the Antimicrobial Peptides in Python bivittatus and Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity. | Antimicrob Agents Chemother | 2017
Evidence 10 Activity

Activity

% Hemolysis
Toxicity
0 %
Hemolytic
Hemolytic_activity: [Ref.28630199]0% hemolysis at 8 µg/ml, 1.7 ± 0.5% hemolysis at 16 µg/ml, 3.1 ± 0.5% hemolysis at 32 µg/ml, 4.0 ± 0.2% hemolysis at 64 µg/ml against chicken red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2017 Aug 24 61(9). pii: e00530-17.