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Peptide record

TPDB09901

Antibacterial Hemolysis Toxicity standard
22 amino acids
Basic Information
3D PDB MODEL
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TPDB09901
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia PD_Hemolysis ToxinPred 3.0
standard
No
A 22-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, PD_Hemolysis, and other sources, with an available 3D structural model.
Sequence
GECIWDAIFHGAKHFLHRLVNP
Physicochemical Analysis
C119H174N34O28S1
QMSTY
H
2560.96
7.41
5
2
10
+0
2.46
0.032
93.18
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
214.76
2
Residue Composition
number
2
A
1
R
1
N
1
D
1
C
1
E
0
Q
2
G
3
H
2
I
2
L
1
K
0
M
2
F
1
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 1 N: 1 D: 1 C: 1 E: 1 Q: 0 G: 2 H: 3 I: 2 L: 2 K: 1 M: 0 F: 2 P: 1 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
22
C119H174N34O28S1
2560.96
7.41
+0
2.46
0.032
Evidence Records 5 records
Evidence 1 Activity

Activity

28.5 ± 0.9% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
28.5 ± 0.9% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Strategic modification of low-activity natural antimicrobial peptides confers antibacterial potential in vitro and in vivo. | Eur J Med Chem | 2023
Evidence 2 Activity

Activity

60% Hemolysis
Toxicity
40 µg/mL
Hemolytic Cytotoxic
60% Hemolysis | 40 | µg/mL | target cell: Tilapia erythrocytes

Target

Tilapia erythrocytes

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 4 Activity

Activity

10% Killing
Toxicity
80 µg/mL
Cytotoxic
10% Killing | 80 | µg/mL | target cell: Tilapia ovary TO2 cells

Target

Tilapia ovary TO2 cells

Source & Reference

NA
DBAASP
Five different piscidins from Nile tilapia, Oreochromis niloticus: analysis of their expressions and biological functions. | PLoS One | 2012
Evidence 5 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis