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Peptide record

TPDB09898

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09898
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
GLLDFFKGAGKELLTHLASQI
Physicochemical Analysis
C105H168N26O29
RNCMPWYV
L
2258.65
7.79
3
2
10
+0
1.36
0.405
120.95
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
2
A
0
R
0
N
1
D
0
C
1
E
1
Q
3
G
1
H
1
I
5
L
2
K
0
M
2
F
0
P
1
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 1 C: 0 E: 1 Q: 1 G: 3 H: 1 I: 1 L: 5 K: 2 M: 0 F: 2 P: 0 S: 1 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C105H168N26O29
2258.65
7.79
+0
1.36
0.405
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
62.5 µM

Target

Escherichia coli ATCC 35218

Source & Reference

NA

Other

Weakly active against E. coli ATCC 35218 (MIC 62.5 uM), but NOT antibiotic-resistant K.pneumoniae ATCC BAA-2814 (MIC >125 uM) and reference stra
Evidence 2 Activity

Activity

MIC
Antibacterial
>125 µM

Target

K.pneumoniae ATCC BAA-2814

Source & Reference

NA

Other

Weakly active against E. coli ATCC 35218 (MIC 62.5 uM), but NOT antibiotic-resistant K.pneumoniae ATCC BAA-2814 (MIC >125 uM) and reference strains of K.pneumoniae ATCC 49472 (MIC 125 uM), S.typhimurium ATCC 14028 (
Evidence 3 Activity

Activity

MIC
Antibacterial
125 µM

Target

K.pneumoniae ATCC 49472

Source & Reference

NA

Other

OT antibiotic-resistant K.pneumoniae ATCC BAA-2814 (MIC >125 uM) and reference strains of K.pneumoniae ATCC 49472 (MIC 125 uM), S.typhimurium ATCC 14028 (MIC 125 uM), Gram+ S.aureus ATCC 12600 or ATCC BAA-2312 (MIC 2
Evidence 4 Activity

Activity

MIC
Antibacterial
125 µM

Target

S.typhimurium ATCC 14028

Source & Reference

NA

Other

TCC BAA-2814 (MIC >125 uM) and reference strains of K.pneumoniae ATCC 49472 (MIC 125 uM), S.typhimurium ATCC 14028 (MIC 125 uM), Gram+ S.aureus ATCC 12600 or ATCC BAA-2312 (MIC 250 uM) and E.faecium ATCC 19434 (MIC 25
Evidence 5 Activity

Activity

MIC
Antibacterial
250 µM

Target

S.aureus ATCC 12600 or ATCC BAA-2312

Source & Reference

NA

Other

ins of K.pneumoniae ATCC 49472 (MIC 125 uM), S.typhimurium ATCC 14028 (MIC 125 uM), Gram+ S.aureus ATCC 12600 or ATCC BAA-2312 (MIC 250 uM) and E.faecium ATCC 19434 (MIC 250 uM). Hemo.lytic HC50 > 250 uM.
Evidence 6 Activity

Activity

MIC
Antibacterial
250 µM

Target

E.faecium ATCC 19434

Source & Reference

NA

Other

rium ATCC 14028 (MIC 125 uM), Gram+ S.aureus ATCC 12600 or ATCC BAA-2312 (MIC 250 uM) and E.faecium ATCC 19434 (MIC 250 uM). Hemo.lytic HC50 > 250 uM.
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
>250 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >250 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Peptidomic Analysis of Skin Secretions of the Caribbean Frogs Leptodactylus insularum and Leptodactylus nesiotus (Leptodactylidae) Identifies an Ocellatin with Broad Spectrum Antimicrobial Activity. | Antibiotics (Basel) | 2020