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Peptide record

TPDB09897

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09897
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LIAGLAANFLPQILCKIARKC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C103H178N28O24S2
DEHMSTWYV
AL
2256.84
9.92
3
0
12
+3
-0.47
1.067
149.05
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
0.06
4
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
1
Q
1
G
0
H
3
I
4
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 4 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21 reviewed residue count
C103H178N28O24S2 sequence-only estimate (linear, free termini)
2256.84 sequence-only estimate (linear, free termini)
9.92 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
-0.47 sequence-only estimate (linear, free termini)
1.067 sequence-only estimate (linear, free termini)
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

B. coagulans ATCC 7050

Source & Reference

NA

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Als
Evidence 2 Activity

Activity

MIC
Antibacterial
7 µg/mL

Target

Escherichia coli MG1655

Source & Reference

NA

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug
Evidence 3 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

V. cholerae

Source & Reference

NA

Other

against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug/ml (Anti-TB) ( Abraham et al.,
Evidence 4 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

B. coagulans ATCC 7050

Source & Reference

Antifungipept

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Als
Evidence 5 Activity

Activity

MIC
Antifungal
7 µg/mL

Target

Escherichia coli MG1655

Source & Reference

Antifungipept

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug
Evidence 6 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

V. cholerae

Source & Reference

Antifungipept

Other

against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug/ml (Anti-TB) ( Abraham et al.,
Evidence 7 Activity

Activity

38% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
38% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Novel antibacterial peptides from the skin secretion of the Indian bicoloured frog Clinotarsus curtipes. | Biochimie | 2014
Evidence 8 Activity

Activity

40% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
40% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 9 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µg/mL
Cytotoxic
50% Cytotoxicity | >100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 10 Activity

Activity

50% Cytotoxicity
Toxicity
75.1±1.46 µg/mL
Cytotoxic
50% Cytotoxicity | 75.1±1.46 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 11 Activity

Activity

37% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
37% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015