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Peptide record

TPDB09897

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09897
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
LIAGLAANFLPQILCKIARKC
Physicochemical Analysis
C103H178N28O24S2
DEHMSTWYV
AL
2256.84
9.92
3
0
12
+3
-1.21
1.067
149.05
Mammalian: 5.5 hour Yeast: 3 min E.coli: 2 min
125
5.54
4
Residue Composition
number
4
A
1
R
1
N
0
D
2
C
0
E
1
Q
1
G
0
H
3
I
4
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 4 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C103H178N28O24S2
2256.84
9.92
+3
-1.21
1.067
Evidence Records 11 records
Evidence 1 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

B. coagulans ATCC 7050

Source & Reference

NA

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Als
Evidence 2 Activity

Activity

MIC
Antibacterial
7 µg/mL

Target

Escherichia coli MG1655

Source & Reference

NA

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug
Evidence 3 Activity

Activity

MIC
Antibacterial
15 µg/mL

Target

V. cholerae

Source & Reference

NA

Other

against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug/ml (Anti-TB) ( Abraham et al.,
Evidence 4 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

B. coagulans ATCC 7050

Source & Reference

Antifungipept

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Als
Evidence 5 Activity

Activity

MIC
Antifungal
7 µg/mL

Target

Escherichia coli MG1655

Source & Reference

Antifungipept

Other

Active against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug
Evidence 6 Activity

Activity

MIC
Antifungal
15 µg/mL

Target

V. cholerae

Source & Reference

Antifungipept

Other

against B. coagulans ATCC 7050 (MIC 6.25 ug/ml), Gram- E. coli MG1655 (MIC 7 ug/ml), and V. cholerae (MIC 15 ug/ml). Hemolytic 37.5%. Also inhibit M. tuberculosis at 12.5 ug/ml (Anti-TB) ( Abraham et al.,
Evidence 7 Activity

Activity

38% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
38% Hemolysis | 200 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Novel antibacterial peptides from the skin secretion of the Indian bicoloured frog Clinotarsus curtipes. | Biochimie | 2014
Evidence 8 Activity

Activity

40% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
40% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 9 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µg/mL
Cytotoxic
50% Cytotoxicity | >100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 10 Activity

Activity

50% Cytotoxicity
Toxicity
75.1±1.46 µg/mL
Cytotoxic
50% Cytotoxicity | 75.1±1.46 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 11 Activity

Activity

37% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
37% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015