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Peptide record

TPDB09894

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09894
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
KKTWWKTWWTKWSQPKKKRKV
Physicochemical Analysis
C139H210N38O27
ANDCEGHILMFY
K
2845.44
11.97
9
0
6
+9
1.13
-2.095
13.81
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
27500
966.46
5
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
0
I
0
L
8
K
0
M
0
F
1
P
1
S
3
T
5
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 0 L: 0 K: 8 M: 0 F: 0 P: 1 S: 1 T: 3 W: 5 Y: 0 V: 1
Chemical Descriptors
21
C139H210N38O27
2845.44
11.97
+9
1.13
-2.095
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >>100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 2 Activity

Activity

50% Cell death
Toxicity
18.6 µM
Cytotoxic
50% Cell death | 18.6 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Analogues of peptide SMAP-29 with comparable antimicrobial potency and reduced cytotoxicity. | Int J Antimicrob Agents | 2011
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
5% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Evidence 4 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.16945333]Non-hemolysis at 200 µM against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochem Biophys Res Commun. 2006 Oct 20 349(2):769-74.