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Peptide record

TPDB09893

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09893
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from AntiBP3 and Peptipedia, with an available 3D structural model.
Sequence
RFRPPIRRPPIRPPFYPPFRP
Physicochemical Analysis
C129H195N39O23
ANDCEQGHLKMSTWV
P
2660.22
12.70
6
0
6
+6
3.96
-1.205
37.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
1490
56.01
1
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
0
L
0
K
0
M
3
F
9
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 3 P: 9 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
21
C129H195N39O23
2660.22
12.70
+6
3.96
-1.205
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

Escherichia coli BW25113 or ATCC 25922

Source & Reference

NA

Other

active against Gram- E. coli BW25113 or ATCC 25922 (MIC 2-4 uM), A. baumannii ATCC 19606 (MIC 16 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae AT
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

A. baumannii ATCC 19606

Source & Reference

NA

Other

active against Gram- E. coli BW25113 or ATCC 25922 (MIC 2-4 uM), A. baumannii ATCC 19606 (MIC 16 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), P-aeruginosa A
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

S. enterica ATCC 14028

Source & Reference

NA

Other

st Gram- E. coli BW25113 or ATCC 25922 (MIC 2-4 uM), A. baumannii ATCC 19606 (MIC 16 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), P-aeruginosa ATCC 27853 (MIC > 64 uM), and S-aure
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µM

Target

Klebsiella pneumoniae ATCC 700603

Source & Reference

NA

Other

922 (MIC 2-4 uM), A. baumannii ATCC 19606 (MIC 16 uM), S. enterica ATCC 14028 (MIC 8 uM), K. pneumoniae ATCC 700603 (MIC 32 uM), P-aeruginosa ATCC 27853 (MIC > 64 uM), and S-aureus ATCC 25923 (MIC > 64 uM). bactericid
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
Search for Shorter Portions of the Proline-Rich Antimicrobial Peptide Fragment Bac5(1-25) That Retain Antimicrobial Activity by Blocking Protein Synthesis. | ChemMedChem | 2019