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Peptide record

TPDB09889

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09889
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, and ToxinPred 3.0, with an available 3D structural model.
Sequence
RIAGLAANFLPQILCKIARKC
Physicochemical Analysis
C103H179N31O24S2
DEHMSTWYV
A
2299.87
10.58
4
0
11
+4
0.16
0.671
130.48
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
5.44
4
Residue Composition
number
4
A
2
R
1
N
0
D
2
C
0
E
1
Q
1
G
0
H
3
I
3
L
2
K
0
M
1
F
1
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 2 N: 1 D: 0 C: 2 E: 0 Q: 1 G: 1 H: 0 I: 3 L: 3 K: 2 M: 0 F: 1 P: 1 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C103H179N31O24S2
2299.87
10.58
+4
0.16
0.671
Evidence Records 4 records
Evidence 1 Activity

Activity

17.4% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
17.4% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µg/mL
Cytotoxic
50% Cytotoxicity | >100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µg/mL
Cytotoxic
50% Cytotoxicity | >100 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structure-Activity Relationship and Mode of Action of a Frog Secreted Antibacterial Peptide B1CTcu5 Using Synthetically and Modularly Modified or Deleted (SMMD) Peptides. | PLoS One | 2015
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
17.4 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 17.4% Hemolysis=200 µM | Cytotoxicity: HEK293: 50%Cytotoxicity>100 µg/ml PBMC: 50%Cytotoxicity=75.1±1.46 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
PLoS One. 2015 May 21 10(5):e0124210.