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Peptide record

TPDB09882

Antibacterial Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09882
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept ToxinPred 3.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
FFGRLKAVFRGARQGWKEHRY
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C122H181N39O26
NDCIMPST
R
2610.03
11.97
7
1
9
+5
2.92
-0.924
41.90
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
6990
2.68
2
Residue Composition
number
2
A
4
R
0
N
0
D
0
C
1
E
1
Q
3
G
1
H
0
I
1
L
2
K
0
M
3
F
0
P
0
S
0
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 4 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 3 H: 1 I: 0 L: 1 K: 2 M: 0 F: 3 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 1
Chemical Descriptors
21 reviewed residue count
C122H181N39O26 sequence-only estimate (linear, free termini)
2610.03 sequence-only estimate (linear, free termini)
11.97 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
2.92 sequence-only estimate (linear, free termini)
-0.924 sequence-only estimate (linear, free termini)
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

V. alginolyticus KCCM2928

Source & Reference

NA

Other

Active against A. salmonicida (RFAS1) (MIC 7.8 uM), V. alginolyticus KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (
Evidence 2 Activity

Activity

MIC
Antibacterial
15.6 µM

Target

V. ordalii KCCM41669

Source & Reference

NA

Other

tive against A. salmonicida (RFAS1) (MIC 7.8 uM), V. alginolyticus KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
7.8 µM

Target

S. iniae FP5228

Source & Reference

NA

Other

(MIC 7.8 uM), V. alginolyticus KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC 15.6 uM). Updated 7/2021
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5 µM

Target

V. harveyi ATCC14126

Source & Reference

NA

Other

KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC 15.6 uM). Updated 7/2021
Evidence 5 Activity

Activity

MIC
Antibacterial
15.6 µM

Target

E. tarda FP4130

Source & Reference

NA

Other

M41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC 15.6 uM). Updated 7/2021
Evidence 6 Activity

Activity

MIC
Antifungal
0.5 µM

Target

V. alginolyticus KCCM2928

Source & Reference

Antifungipept

Other

Active against A. salmonicida (RFAS1) (MIC 7.8 uM), V. alginolyticus KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (
Evidence 7 Activity

Activity

MIC
Antifungal
15.6 µM

Target

V. ordalii KCCM41669

Source & Reference

Antifungipept

Other

tive against A. salmonicida (RFAS1) (MIC 7.8 uM), V. alginolyticus KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC
Evidence 8 Activity

Activity

MIC
Antifungal
7.8 µM

Target

S. iniae FP5228

Source & Reference

Antifungipept

Other

(MIC 7.8 uM), V. alginolyticus KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC 15.6 uM). Updated 7/2021
Evidence 9 Activity

Activity

MIC
Antifungal
0.5 µM

Target

V. harveyi ATCC14126

Source & Reference

Antifungipept

Other

KCCM2928 (MIC 0.5 uM), V. ordalii KCCM41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC 15.6 uM). Updated 7/2021
Evidence 10 Activity

Activity

MIC
Antifungal
15.6 µM

Target

E. tarda FP4130

Source & Reference

Antifungipept

Other

M41669 (MIC 15.6 uM), S. iniae FP5228 (MIC 7.8 uM), V. harveyi ATCC14126 (MIC 0.5 uM) and E. tarda FP4130 (MIC 15.6 uM). Updated 7/2021
Evidence 11 Activity

Activity

0% Hemolysis
Toxicity
63 µM
Hemolytic Cytotoxic
0% Hemolysis | 63 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Gene expressions and biological activities of two novel antimicrobial peptides (AMPs) isolated from leucocytes of the rock bream, Oplegnathus fasciatus | Aquaculture | 2018
Evidence 12 Activity

Activity

<5% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
<5% Hemolysis | 125 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Gene expressions and biological activities of two novel antimicrobial peptides (AMPs) isolated from leucocytes of the rock bream, Oplegnathus fasciatus | Aquaculture | 2018
Evidence 13 Activity

Activity

70% Hemolysis
Toxicity
500 µM
Hemolytic Cytotoxic
70% Hemolysis | 500 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Gene expressions and biological activities of two novel antimicrobial peptides (AMPs) isolated from leucocytes of the rock bream, Oplegnathus fasciatus | Aquaculture | 2018
Evidence 14 Activity

Activity

100% Hemolysis
Toxicity
1000 µM
Hemolytic Cytotoxic
100% Hemolysis | 1000 | µM | target cell: Fish erythrocytes

Target

Fish erythrocytes

Source & Reference

NA
DBAASP
Gene expressions and biological activities of two novel antimicrobial peptides (AMPs) isolated from leucocytes of the rock bream, Oplegnathus fasciatus | Aquaculture | 2018