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Peptide record

TPDB09881

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09881
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFAWNVCVYRNGVRVCHRRAN
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C107H165N39O26S2
DEQILKMPST
RV
2477.85
11.00
5
0
9
+4
2.61
-0.310
64.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7115
2.87
6
Residue Composition
number
2
A
4
R
3
N
0
D
2
C
0
E
0
Q
2
G
1
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 4 N: 3 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 4
Chemical Descriptors
21 reviewed residue count
C107H165N39O26S2 sequence-only estimate (linear, free termini)
2477.85 sequence-only estimate (linear, free termini)
11.00 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
2.61 sequence-only estimate (linear, free termini)
-0.310 sequence-only estimate (linear, free termini)
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium ATCC14028

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
0.25 µg/mL

Target

S. enteritidis CVCC3377

Source & Reference

dbAMP DRAMP

Other

r CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

S. pullorum CVCC1789 or CVCC1802

Source & Reference

dbAMP DRAMP

Other

ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. choleraesuis CVCC503

Source & Reference

dbAMP DRAMP

Other

enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or
Evidence 5 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Pseudomonas aeruginosa CICC10419 or CICC21630

Source & Reference

dbAMP DRAMP

Other

S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16
Evidence 6 Activity

Activity

MIC
Antibacterial
0.25-16 µg/mL

Target

Staphylococcus aureus ATCC43300 MRSA or ATCC25923

Source & Reference

dbAMP DRAMP

Other

aesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC663
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

S. suis CVCC606

Source & Reference

dbAMP DRAMP

Other

CC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albi
Evidence 8 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP DRAMP

Other

(MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 64 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. typhimurium ATCC14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/m
Evidence 10 Activity

Activity

MIC
Antifungal
0.25 µg/mL

Target

S. enteritidis CVCC3377

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

r CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml),
Evidence 11 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

S. pullorum CVCC1789 or CVCC1802

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/
Evidence 12 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. choleraesuis CVCC503

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or
Evidence 13 Activity

Activity

MIC
Antifungal
4-8 µg/mL

Target

Pseudomonas aeruginosa CICC10419 or CICC21630

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16
Evidence 14 Activity

Activity

MIC
Antifungal
0.25-16 µg/mL

Target

Staphylococcus aureus ATCC43300 MRSA or ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC663
Evidence 15 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

S. suis CVCC606

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

CC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albi
Evidence 16 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 64 ug/ml).
Evidence 17 Activity

Activity

0.04% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
0.04% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis. | Sci Rep | 2017
Evidence 18 Activity

Activity

1.9% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
1.9% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis. | Sci Rep | 2017
Evidence 19 Activity

Activity

0.19% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
0.19% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Dual Antibacterial Activities and Biofilm Eradication of a Marine Peptide-N6NH 2 and Its Analogs against Multidrug-Resistant Aeromonas veronii. | Int J Mol Sci | 2020
Evidence 20 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)

Source & Reference

NA
DRAMP
Mar Drugs. 2020 Dec 17 18(12):650. doi: 10.3390/md18120650.
Evidence 21 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.33348729]The hemolysis of N6NH2 towards mouse erythrocytes was 0.19% at a concentration of 256 µg/mL, lower than that of N6 (1.9%), indicating their low hemolytic activity | Cytotoxicity: [Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2020 Dec 17 18(12):650. doi: 10.3390/md18120650.