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Peptide record

TPDB09881

Antibacterial Anticancer Antifungal Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09881
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 DRAMP Peptipedia Antifungipept CAFPdb dbAMP
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, DRAMP, Peptipedia, and other sources, with an available 3D structural model.
Sequence
GFAWNVCVYRNGVRVCHRRAN
Physicochemical Analysis
C107H165N39O26S2
DEQILKMPST
RV
2477.85
11.00
5
0
9
+4
1.02
-0.310
64.76
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
7115
287.14
6
Residue Composition
number
2
A
4
R
3
N
0
D
2
C
0
E
0
Q
2
G
1
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
1
W
1
Y
4
V
Amino Acid Distribution
A: 2 R: 4 N: 3 D: 0 C: 2 E: 0 Q: 0 G: 2 H: 1 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 4
Chemical Descriptors
21
C107H165N39O26S2
2477.85
11.00
+4
1.02
-0.310
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. typhimurium ATCC14028

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
0.25 µg/mL

Target

S. enteritidis CVCC3377

Source & Reference

dbAMP DRAMP

Other

r CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml),
Evidence 3 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

S. pullorum CVCC1789 or CVCC1802

Source & Reference

dbAMP DRAMP

Other

ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

S. choleraesuis CVCC503

Source & Reference

dbAMP DRAMP

Other

enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or
Evidence 5 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Pseudomonas aeruginosa CICC10419 or CICC21630

Source & Reference

dbAMP DRAMP

Other

S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16
Evidence 6 Activity

Activity

MIC
Antibacterial
0.25-16 µg/mL

Target

Staphylococcus aureus ATCC43300 MRSA or ATCC25923

Source & Reference

dbAMP DRAMP

Other

aesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC663
Evidence 7 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

S. suis CVCC606

Source & Reference

dbAMP DRAMP

Other

CC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albi
Evidence 8 Activity

Activity

MIC
Antibacterial
0.5 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP DRAMP

Other

(MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 64 ug/ml).
Evidence 9 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. typhimurium ATCC14028

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
- bacteria E. coli CVCC195 or CVCC1515 or CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/m
Evidence 10 Activity

Activity

MIC
Antifungal
0.25 µg/mL

Target

S. enteritidis CVCC3377

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

r CICC21530 serotype O157:H7 (MIC 0.5-1.0 ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml),
Evidence 11 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

S. pullorum CVCC1789 or CVCC1802

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ug/ml), S. typhimurium ATCC14028 (MIC 2 ug/ml), S. enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/
Evidence 12 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

S. choleraesuis CVCC503

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

enteritidis CVCC3377 (MIC 0.25 ug/ml), S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or
Evidence 13 Activity

Activity

MIC
Antifungal
4-8 µg/mL

Target

Pseudomonas aeruginosa CICC10419 or CICC21630

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

S. pullorum CVCC1789 or CVCC1802 (MIC 0.5 ug/ml), S. choleraesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16
Evidence 14 Activity

Activity

MIC
Antifungal
0.25-16 µg/mL

Target

Staphylococcus aureus ATCC43300 MRSA or ATCC25923

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

aesuis CVCC503 (MIC 2 ug/ml), P. aeruginosa CICC10419 or CICC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC663
Evidence 15 Activity

Activity

MIC
Antifungal
16 µg/mL

Target

S. suis CVCC606

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

CC21630 (MIC 4-8 ug/ml), Gram+ S. aureus ATCC43300 MRSA or ATCC25923 (MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albi
Evidence 16 Activity

Activity

MIC
Antifungal
0.5 µg/mL

Target

B. subtilis ATCC6633

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 0.25-16 ug/ml), S. suis CVCC606 (MIC 16 ug/ml), E. faecium CMCC1.2136 (MIC 4 ug/ml), B. subtilis ATCC6633 (MIC 0.5 ug/ml), fungi C. albicans CGMCC2.2411 (MIC 64 ug/ml).
Evidence 17 Activity

Activity

0.04% Hemolysis
Toxicity
128 µg/mL
Hemolytic Cytotoxic
0.04% Hemolysis | 128 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis. | Sci Rep | 2017
Evidence 18 Activity

Activity

1.9% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
1.9% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis. | Sci Rep | 2017
Evidence 19 Activity

Activity

0.19% Hemolysis
Toxicity
256 µg/mL
Hemolytic Cytotoxic
0.19% Hemolysis | 256 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Dual Antibacterial Activities and Biofilm Eradication of a Marine Peptide-N6NH 2 and Its Analogs against Multidrug-Resistant Aeromonas veronii. | Int J Mol Sci | 2020
Evidence 20 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)

Source & Reference

NA
DRAMP
Mar Drugs. 2020 Dec 17 18(12):650. doi: 10.3390/md18120650.
Evidence 21 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: [Ref.33348729]The hemolysis of N6NH2 towards mouse erythrocytes was 0.19% at a concentration of 256 µg/mL, lower than that of N6 (1.9%), indicating their low hemolytic activity | Cytotoxicity: [Ref.33348729]Had very low cytotoxicity to mouse peritoneal RAW 264.7 macrophages (cell survival rate >93.35%)

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2020 Dec 17 18(12):650. doi: 10.3390/md18120650.