TPDB

3D PDB MODEL

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TPDB ID TPDB09871

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GIFGKILGVGKKVLCGLSGVC

FASTA

>TPDB09871|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=21
GIFGKILGVGKKVLCGLSGVC

Formula C93H162N24O23S2

Absent Amino Acids ARNDEQHMPTWY

Common Amino Acids G

Mass 2048.58

PI 9.80

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +3

Boman Index -0.54

Hydrophobicity 1.233

Aliphatic Index 134.29

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.10

Polar Residues 3

number

0

A

0

R

0

N

0

D

2

C

0

E

0

Q

6

G

0

H

2

I

3

L

3

K

0

M

1

F

0

P

1

S

0

T

0

W

0

Y

3

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 2 L: 3 K: 3 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 3

Length

21

Formula

C93H162N24O23S2

Mass

2048.58

PI

9.80

Net Charge

+3

Boman Index

-0.54

Hydrophobicity

1.233

Evidence 1 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 7.3 %

Hemolysis Raw

[Ref.17272268] RCH=21.6 ± 7.3% against rabbit red blood cells. RCH, red cell hemolysis.

Target

RBC Target rabbit red blood cells

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 22% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

22% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 3 Activity

Activity

Activity Endpoint (25.1±9.2)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(25.1±9.2)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin. | Mol Cell Proteomics | 2007

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.17272268] RCH=21.6 ± 7.3% against rabbit red blood cells. RCH, red cell hemolysis.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Evidence 5 Hemolysis

Activity

Activity Measurement 7.3 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.17272268] RCH=21.6 ± 7.3% against rabbit red blood cells. RCH, red cell hemolysis.

Detail Source Activity Hemolysis

Target

RBC Target rabbit red blood cells

Source & Reference

source HemoPI PD_Hemolysis

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Source DRAMP4

Database Source PD_Hemolysis