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Peptide record

TPDB09868

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09868
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLSGVLGVGKKIVCGLSGLC
Physicochemical Analysis
C87H157N23O24S2
ARNDEQHMFPTWY
G
1973.46
9.11
2
0
9
+2
-1.08
1.395
152.86
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.33
4
Residue Composition
number
0
A
0
R
0
N
0
D
2
C
0
E
0
Q
6
G
0
H
1
I
5
L
2
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 1 L: 5 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 3
Chemical Descriptors
21
C87H157N23O24S2
1973.46
9.11
+2
-1.08
1.395
Evidence Records 25 records
Evidence 1 Activity

Activity

MIC
Antibacterial
5.2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against Gram- bacteria E. coli (MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16
Evidence 3 Activity

Activity

MIC
Antibacterial
5.2 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

led P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml),
Evidence 4 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP

Other

ia S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 5 Activity

Activity

MIC
Antibacterial
128 µg/mL

Target

S.enteritidis

Source & Reference

dbAMP DRAMP

Other

ast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 6 Activity

Activity

MIC
Antibacterial
16-32 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP

Other

so Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 7 Activity

Activity

MIC
Antifungal
5.2 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against Gram- bacteria E. coli (MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 8 Activity

Activity

MIC
Antifungal
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16
Evidence 9 Activity

Activity

MIC
Antifungal
5.2 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

led P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml),
Evidence 10 Activity

Activity

MIC
Antifungal
8-16 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ia S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 11 Activity

Activity

MIC
Antifungal
128 µg/mL

Target

S.enteritidis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 12 Activity

Activity

MIC
Antifungal
16-32 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

so Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 13 Activity

Activity

MIC
Antiparasitic
5.2 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against Gram- bacteria E. coli (MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 14 Activity

Activity

MIC
Antiparasitic
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16
Evidence 15 Activity

Activity

MIC
Antiparasitic
5.2 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

led P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml),
Evidence 16 Activity

Activity

MIC
Antiparasitic
8-16 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

ia S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 17 Activity

Activity

MIC
Antiparasitic
128 µg/mL

Target

S.enteritidis

Source & Reference

DRAMP

Other

ast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 18 Activity

Activity

MIC
Antiparasitic
16-32 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

DRAMP

Other

so Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 19 Activity

Activity

MIC
Antiviral
5.2 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against Gram- bacteria E. coli (MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC
Evidence 20 Activity

Activity

MIC
Antiviral
10.4 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

MIC 5.2 ug/ml), B. pyocyaneus (now called P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16
Evidence 21 Activity

Activity

MIC
Antiviral
5.2 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

led P. aeruginosa) (MIC 10.4 ug/ml), Gram+ bacteria S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml),
Evidence 22 Activity

Activity

MIC
Antiviral
8-16 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

DRAMP

Other

ia S. aureus (MIC 10.4 ug/ml), and yeast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 23 Activity

Activity

MIC
Antiviral
128 µg/mL

Target

S.enteritidis

Source & Reference

DRAMP

Other

ast C. albicans (MIC 5.2 ug/ml). Also Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 24 Activity

Activity

MIC
Antiviral
16-32 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

DRAMP

Other

so Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml) ( MDPI ).
Evidence 25 Activity

Activity

50% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022