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Peptide record

TPDB09867

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09867

Activity

Antibacterial Anticancer Antifungal Antiparasitic Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLLSGILGAGKHIVCGLSGLC

FASTA

>TPDB09867|Antibacterial;Anticancer;Antifungal;Antiparasitic;Toxicity|length=21
GLLSGILGAGKHIVCGLSGLC

Formula C86H150N24O24S2

Absent Amino Acids RNDEQMFPTWY

Common Amino Acids G

Mass 1968.40

PI 8.30

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -1.73

Hydrophobicity 1.329

Aliphatic Index 148.57

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.35

Polar Residues 4

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 1 I: 2 L: 5 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1

Length

Formula

C86H150N24O24S2

Mass

1968.40

8.30

Net Charge

Boman Index

-1.73

Hydrophobicity

1.329

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 25 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC 25922 (MIC 25 uM), S.aureus NCTC 8325 (MIC >100 uM), and C.albicans ATCC 90028 (MIC > 100 uM). Histamine re

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism S.aureus NCTC 8325

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 25 uM), S.aureus NCTC 8325 (MIC >100 uM), and C.albicans ATCC 90028 (MIC > 100 uM). Histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 25 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC 25922 (MIC 25 uM), S.aureus NCTC 8325 (MIC >100 uM), and C.albicans ATCC 90028 (MIC > 100 uM). Histamine re

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism S.aureus NCTC 8325

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 25 uM), S.aureus NCTC 8325 (MIC >100 uM), and C.albicans ATCC 90028 (MIC > 100 uM). Histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 25 µM

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E. coli ATCC 25922 (MIC 25 uM), S.aureus NCTC 8325 (MIC >100 uM), and C.albicans ATCC 90028 (MIC > 100 uM). Histamine re

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism S.aureus NCTC 8325

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 25 uM), S.aureus NCTC 8325 (MIC >100 uM), and C.albicans ATCC 90028 (MIC > 100 uM). Histamine release.

Evidence 7 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007

Evidence 8 Activity

Activity

Activity Endpoint (1.6±0.5)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(1.6±0.5)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007

Evidence 9 Activity

Activity

Activity Endpoint LC50

Detail Source Activity Toxicity

Activity Measurement 295 µM

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref:16621155] LC50=295 µM against human erythrocytes

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2006 Sep 27(9):2111-2117.