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Peptide record

TPDB09866

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09866

Activity

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLLSGILGAGKHIICGLSGLC

FASTA

>TPDB09866|Antibacterial;Anticancer;Antifungal;Antiparasitic;Hemolysis;Toxicity|length=21
GLLSGILGAGKHIICGLSGLC

Formula C87H152N24O24S2

Absent Amino Acids RNDEQMFPTWYV

Common Amino Acids G

Mass 1982.43

PI 8.30

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +1

Boman Index -2.11

Hydrophobicity 1.343

Aliphatic Index 153.33

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.31

Polar Residues 4

number

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 1 I: 3 L: 5 K: 1 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C87H152N24O24S2

Mass

1982.43

8.30

Net Charge

Boman Index

-2.11

Hydrophobicity

1.343

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µM

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Al

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >100 µg/mL

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.1 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µM

Target

Target Organism E.coli

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Al

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >100 µg/mL

Target

Target Organism B.subtilis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.1 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µM

Target

Target Organism E.coli

Source & Reference

Database Source DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets.

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Al

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism S.aureus

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement >100 µg/mL

Target

Target Organism B.subtilis

Source & Reference

Database Source DRAMP

Other

Evidence Text

Active against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 1.1 µM

Target

Target Organism Candida albicans

Source & Reference

Database Source DRAMP

Other

Evidence Text

against E.coli (MIC>100 uM), S.aureus (MIC >100 ug/ml), B.subtilis (MIC >100 ug/ml), and C. albicans (MIC 1.1 uM). Also histamine release.

Evidence 13 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 7.7 %

Hemolysis Raw

[Ref.17272268] RCH=65.5 ± 7.7% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Target

RBC Target rabbit red blood cells

Source & Reference

Database Source Hemolytik APD_complete APD_hemolytic PD_Hemolysis

Source DRAMP4

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 66% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

66% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007

Evidence 15 Activity

Activity

Activity Endpoint (9.3±2.8)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(9.3±2.8)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007

Evidence 16 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.17272268] RCH=65.5 ± 7.7% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Evidence 17 Hemolysis

Activity

Activity Measurement 7.7 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.17272268] RCH=65.5 ± 7.7% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Detail Source Activity Hemolysis

Target

RBC Target rabbit red blood cells

Source & Reference

source APD_complete APD_hemolytic HemoPI PD_Hemolysis

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Source DRAMP4

Database Source APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label	Source Definition
Hemolysis	APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.