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Peptide record

TPDB09861

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09861
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia SATPdb AFP-GFuse Antifungipept CAFPdb HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RSTEDIIKSISGGGFLNAMNA
Physicochemical Analysis
C92H153N27O32S1
CQHPWYV
GIS
2181.45
7.01
2
2
8
+0
3.26
-0.052
83.81
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
6
Residue Composition
number
2
A
1
R
2
N
1
D
0
C
1
E
0
Q
3
G
0
H
3
I
1
L
1
K
1
M
1
F
0
P
3
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 1 N: 2 D: 1 C: 0 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 1 K: 1 M: 1 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
21
C92H153N27O32S1
2181.45
7.01
+0
3.26
-0.052
Evidence Records 5 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

0% Killing
Toxicity
25 µM
Cytotoxic
0% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>128 µg/mL
Cytotoxic
50% Cell death | >128 | µg/mL | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 4 Activity

Activity

50% Cell death
Toxicity
>128 µg/mL
Cytotoxic
50% Cell death | >128 | µg/mL | target cell: Human microvascular endothelial cells HMEC-1

Target

Human microvascular endothelial cells HMEC-1

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis