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Peptide record

TPDB09859

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09859
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLSGILGAGKQKVCGLSGLC
Physicochemical Analysis
C85H152N24O25S2
RNDEHMFPTWY
G
1974.41
9.11
2
0
8
+2
-0.81
0.914
130.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
6.33
5
Residue Composition
number
1
A
0
R
0
N
0
D
2
C
0
E
1
Q
6
G
0
H
1
I
5
L
2
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 1 G: 6 H: 0 I: 1 L: 5 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C85H152N24O25S2
1974.41
9.11
+2
-0.81
0.914
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
9.4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml
Evidence 2 Activity

Activity

MIC
Antibacterial
18.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 3 Activity

Activity

MIC
Antibacterial
37.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP

Other

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 4 Activity

Activity

MIC
Antibacterial
4.7 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP

Other

st E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 5 Activity

Activity

MIC
Antifungal
9.4 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml
Evidence 6 Activity

Activity

MIC
Antifungal
18.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 7 Activity

Activity

MIC
Antifungal
37.5 µg/mL

Target

B. subtilis

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 8 Activity

Activity

MIC
Antifungal
4.7 µg/mL

Target

Candida albicans

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

st E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 9 Activity

Activity

MIC
Antiparasitic
9.4 µg/mL

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml
Evidence 10 Activity

Activity

MIC
Antiparasitic
18.8 µg/mL

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 11 Activity

Activity

MIC
Antiparasitic
37.5 µg/mL

Target

B. subtilis

Source & Reference

DRAMP

Other

active against E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 12 Activity

Activity

MIC
Antiparasitic
4.7 µg/mL

Target

Candida albicans

Source & Reference

DRAMP

Other

st E. coli (MIC 9.4 ug/ml), S. aureus (MIC 18.8 ug/ml), B. subtilis (MIC 37.5 ug/ml), and C. albicans (MIC 4.7 ug/ml). Also histamine release.
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
2.6 %
[Ref.17272268] RCH=87.2 ± 2.6% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Target

rabbit red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

87% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
87% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007
Evidence 15 Activity

Activity

(2.9±1.5)% degranulation
Toxicity
50 µg/mL
Cytotoxic
(2.9±1.5)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Human mast cells

Source & Reference

NA
DBAASP
Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.17272268] RCH=87.2 ± 2.6% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Cell Proteomics. 2007 May 6(5):882-894.
Evidence 17 Hemolysis

Activity

2.6 %
% Hemolysis
[Ref.17272268] RCH=87.2 ± 2.6% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.
Hemolysis

Target

rabbit red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Mol Cell Proteomics. 2007 May 6(5):882-894.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.