Back to search

Peptide record

TPDB09851

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09851
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb APD_complete APD_hemolytic Hemolytic2
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
RWCVYAYVRIRGVLVRYRRCW
Physicochemical Analysis
C128H197N41O25S2
NDEQHKMFPST
R
2774.35
11.11
6
0
12
+6
-2.89
-0.057
97.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
15595
562.11
5
Residue Composition
number
1
A
6
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
1
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
3
Y
4
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 3 V: 4
Chemical Descriptors
21
C128H197N41O25S2
2774.35
11.11
+6
-2.89
-0.057
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.6 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
active against L. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µg/mL

Target

Escherichia coli ML-35p

Source & Reference

dbAMP DRAMP

Other

active against L. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
4.5 µg/mL

Target

Candida albicans 820

Source & Reference

dbAMP DRAMP

Other

. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 4 Activity

Activity

MIC
Antifungal
0.6 µg/mL

Target

L. monocytogenes EGD

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
active against L. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
4 µg/mL

Target

Escherichia coli ML-35p

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

active against L. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 6 Activity

Activity

MIC
Antifungal
4.5 µg/mL

Target

Candida albicans 820

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 7 Activity

Activity

MIC
Antiparasitic
0.6 µg/mL

Target

L. monocytogenes EGD

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
active against L. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 8 Activity

Activity

MIC
Antiparasitic
4 µg/mL

Target

Escherichia coli ML-35p

Source & Reference

DRAMP

Other

active against L. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
4.5 µg/mL

Target

Candida albicans 820

Source & Reference

DRAMP

Other

. monocytogenes EGD (MIC 0.6 ug/ml), Gram-negative E. coli ML-35p (MIC 4 ug/ml) and fungi C. albicans 820 (MIC 4.5 ug/ml).
Evidence 10 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus | J Biomed Sci | 2024
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
29.2±2.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 29.2±2.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus | J Biomed Sci | 2024
Evidence 12 Hemolysis

Source & Reference

APD_complete APD_hemolytic
APD_complete APD_hemolytic

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.