Back to search

Peptide record

TPDB09850

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09850
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GCRFCCNCCPNMSGCGVCCRF
Physicochemical Analysis
C86H135N29O25S9
ADEQHILKTWY
C
2263.74
7.85
2
0
4
+2
-1.27
0.576
13.81
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
500
22.09
11
Residue Composition
number
0
A
2
R
2
N
0
D
8
C
0
E
0
Q
3
G
0
H
0
I
0
L
0
K
1
M
2
F
1
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 2 D: 0 C: 8 E: 0 Q: 0 G: 3 H: 0 I: 0 L: 0 K: 0 M: 1 F: 2 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C86H135N29O25S9
2263.74
7.85
+2
-1.27
0.576
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
11-22 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
oca, P-aeruginosa, S-arizonae, S- choleraesuis, S-typhimurium, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonn
Evidence 2 Activity

Activity

MIC
Antibacterial
22 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP

Other

choleraesuis, S-typhimurium, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enteroco
Evidence 3 Activity

Activity

MIC
Antibacterial
11 µM

Target

P. shigelloides

Source & Reference

dbAMP DRAMP

Other

, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamento
Evidence 4 Activity

Activity

MIC
Antibacterial
22 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP

Other

E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44
Evidence 5 Activity

Activity

MIC
Antibacterial
44 µM

Target

S. sonnei

Source & Reference

dbAMP DRAMP

Other

-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albica
Evidence 6 Activity

Activity

MIC
Antibacterial
22 µM

Target

Y. enterocolitica

Source & Reference

dbAMP DRAMP

Other

(MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albicans (MIC > 44 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
44 µM

Target

A. niger

Source & Reference

dbAMP DRAMP

Other

neri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albicans (MIC > 44 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
11-22 µM

Target

Escherichia coli

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
oca, P-aeruginosa, S-arizonae, S- choleraesuis, S-typhimurium, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonn
Evidence 9 Activity

Activity

MIC
Antifungal
22 µM

Target

Klebsiella pneumoniae

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

choleraesuis, S-typhimurium, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enteroco
Evidence 10 Activity

Activity

MIC
Antifungal
11 µM

Target

P. shigelloides

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamento
Evidence 11 Activity

Activity

MIC
Antifungal
22 µM

Target

S. flexneri

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44
Evidence 12 Activity

Activity

MIC
Antifungal
44 µM

Target

S. sonnei

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albica
Evidence 13 Activity

Activity

MIC
Antifungal
22 µM

Target

Y. enterocolitica

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albicans (MIC > 44 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
44 µM

Target

A. niger

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

neri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albicans (MIC > 44 uM).
Evidence 15 Activity

Activity

MIC
Antiparasitic
11-22 µM

Target

Escherichia coli

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
oca, P-aeruginosa, S-arizonae, S- choleraesuis, S-typhimurium, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonn
Evidence 16 Activity

Activity

MIC
Antiparasitic
22 µM

Target

Klebsiella pneumoniae

Source & Reference

DRAMP

Other

choleraesuis, S-typhimurium, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enteroco
Evidence 17 Activity

Activity

MIC
Antiparasitic
11 µM

Target

P. shigelloides

Source & Reference

DRAMP

Other

, S-marcescens (MIC >44 uM), E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamento
Evidence 18 Activity

Activity

MIC
Antiparasitic
22 µM

Target

S. flexneri

Source & Reference

DRAMP

Other

E. coli 3 strains (MIC 11-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44
Evidence 19 Activity

Activity

MIC
Antiparasitic
44 µM

Target

S. sonnei

Source & Reference

DRAMP

Other

-22 uM), K. pneumoniae (MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albica
Evidence 20 Activity

Activity

MIC
Antiparasitic
22 µM

Target

Y. enterocolitica

Source & Reference

DRAMP

Other

(MIC 22 uM), P. shigelloides (MIC 11 uM), S. flexneri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albicans (MIC > 44 uM).
Evidence 21 Activity

Activity

MIC
Antiparasitic
44 µM

Target

A. niger

Source & Reference

DRAMP

Other

neri (MIC 22 uM), S. sonnei (MIC 44 uM), Y. enterocolitica (MIC 22 uM), filamentous fungi A. niger (MIC 44 uM) and yeast C-albicans (MIC > 44 uM).
Evidence 22 Activity

Activity

0% Hemolysis
Toxicity
44 µM
Hemolytic Cytotoxic
0% Hemolysis | 44 | µM | target cell: Hybrid striped bass erythrocytes

Target

Hybrid striped bass erythrocytes

Source & Reference

NA
DBAASP
Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. | J Biol Chem | 2005
Evidence 23 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.15546886] It displays essentially no hemolytic activity toward HSB erythrocytes

Target

erythrocytes

Source & Reference

NA
DRAMP
Eur J Biochem. 2002 Apr 269(8):2232-2237.##J Biol Chem. 2005 Mar 11 280(10):9272-9282.