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Peptide record

TPDB09848

Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09848
Antibacterial Anticancer Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia Antifungipept APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GLLDFVTGVGKDIFAQLIKQI
Physicochemical Analysis
C107H175N25O29
RNCEHMPSWY
GIL
2275.72
6.87
2
2
11
-0
0.87
0.810
143.81
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
0
N
2
D
0
C
0
E
2
Q
3
G
0
H
3
I
3
L
2
K
0
M
2
F
0
P
0
S
1
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 2 G: 3 H: 0 I: 3 L: 3 K: 2 M: 0 F: 2 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 2
Chemical Descriptors
21
C107H175N25O29
2275.72
6.87
-0
0.87
0.810
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli and S. aureus (MIC 64 uM). Updated 10/2016.
Evidence 2 Activity

Activity

MIC
Antifungal
64 µM

Target

Staphylococcus aureus

Source & Reference

dbAMP DRAMP Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli and S. aureus (MIC 64 uM). Updated 10/2016.
Evidence 3 Activity

Activity

MIC
Antiparasitic
64 µM

Target

Staphylococcus aureus

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli and S. aureus (MIC 64 uM). Updated 10/2016.
Evidence 4 Activity

Activity

HC50
Hemolysis
14.3 µM
[Ref.17884127] HC50 = 14.3 µM against human O+ red blood cells

Target

human O+ red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon 2007 50: 1095-1104.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
14.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 14.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Purification, characterization and homology analysis of ocellatin 4, a cytolytic peptide from the skin secretion of the frog Leptodactylus ocellatus. | Toxicon | 2007
Evidence 6 Activity

Activity

HC50
Toxicity
14.3 µM
Hemolytic
Hemolytic_activity: [Ref.17884127] HC50 = 14.3 µM against human O+ red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon 2007 50: 1095-1104.
Evidence 7 Hemolysis

Activity

14.3 µM
HC50
[Ref.17884127] HC50 = 14.3 µM against human O+ red blood cells
Hemolysis

Target

human O+ red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Toxicon 2007 50: 1095-1104.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.