Back to search

Peptide record

TPDB09847

Antibacterial Anticancer Antifungal Antiparasitic Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09847
Antibacterial Anticancer Antifungal Antiparasitic Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept CAFPdb ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GGAGHVPEYFVGIGTPISFYG
Physicochemical Analysis
C101H141N23O28
RNDCQLKMW
G
2125.37
5.13
1
1
9
-1
-0.58
0.400
69.52
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
140.21
4
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
1
E
0
Q
6
G
1
H
2
I
0
L
0
K
0
M
2
F
2
P
1
S
1
T
0
W
2
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 6 H: 1 I: 2 L: 0 K: 0 M: 0 F: 2 P: 2 S: 1 T: 1 W: 0 Y: 2 V: 2
Chemical Descriptors
21
C101H141N23O28
2125.37
5.13
-1
-0.58
0.400
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.08-5 µg/mL

Target

Escherichia coli BM21

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
ted by E. coli AY25 to inhibit the growth of other Gram-negative bacteria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (
Evidence 2 Activity

Activity

MIC
Antibacterial
0.02-2.5 µg/mL

Target

Escherichia coli AB1133

Source & Reference

dbAMP DRAMP

Other

e growth of other Gram-negative bacteria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01
Evidence 3 Activity

Activity

MIC
Antibacterial
0.04-2.5 µg/mL

Target

Escherichia coli RYC816

Source & Reference

dbAMP DRAMP

Other

ria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01 ug/ml).
Evidence 4 Activity

Activity

MIC
Antibacterial
0.01 µg/mL

Target

S. newport

Source & Reference

dbAMP DRAMP

Other

(MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01 ug/ml).
Evidence 5 Activity

Activity

MIC
Antifungal
0.08-5 µg/mL

Target

Escherichia coli BM21

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
ted by E. coli AY25 to inhibit the growth of other Gram-negative bacteria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (
Evidence 6 Activity

Activity

MIC
Antifungal
0.02-2.5 µg/mL

Target

Escherichia coli AB1133

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

e growth of other Gram-negative bacteria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01
Evidence 7 Activity

Activity

MIC
Antifungal
0.04-2.5 µg/mL

Target

Escherichia coli RYC816

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

ria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01 ug/ml).
Evidence 8 Activity

Activity

MIC
Antifungal
0.01 µg/mL

Target

S. newport

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

(MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01 ug/ml).
Evidence 9 Activity

Activity

MIC
Antiparasitic
0.08-5 µg/mL

Target

Escherichia coli BM21

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
ted by E. coli AY25 to inhibit the growth of other Gram-negative bacteria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (
Evidence 10 Activity

Activity

MIC
Antiparasitic
0.02-2.5 µg/mL

Target

Escherichia coli AB1133

Source & Reference

DRAMP

Other

e growth of other Gram-negative bacteria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01
Evidence 11 Activity

Activity

MIC
Antiparasitic
0.04-2.5 µg/mL

Target

Escherichia coli RYC816

Source & Reference

DRAMP

Other

ria. Active against E. coli BM21 (MIC 0.08-5 ug/ml), E. coli AB1133 (MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01 ug/ml).
Evidence 12 Activity

Activity

MIC
Antiparasitic
0.01 µg/mL

Target

S. newport

Source & Reference

DRAMP

Other

(MIC 0.02-2.5 ug/ml), E. coli RYC816 (MIC 0.04-2.5 ug/ml), E. coli AY29 (0.04 in LB), and S. newport (MIC 0.01 ug/ml).
Evidence 13 Activity

Activity

Toxicity
Cytotoxic
- | NA | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Protective Ability of Biogenic Antimicrobial Peptide Microcin J25 Against Enterotoxigenic Escherichia Coli-Induced Intestinal Epithelial Dysfunction and Inflammatory Responses IPEC-J2 Cells. | Front Cell Infect Microbiol | 2018
Evidence 14 Activity

Activity

4.16% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
4.16% Hemolysis | 512 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Biosynthetic Microcin J25 Exerts Strong Antibacterial, Anti-Inflammatory Activities, Low Cytotoxicity Without Increasing Drug-Resistance to Bacteria Target. | Front Immunol | 2022
Evidence 15 Activity

Activity

4.07% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
4.07% Hemolysis | 512 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Biosynthetic Microcin J25 Exerts Strong Antibacterial, Anti-Inflammatory Activities, Low Cytotoxicity Without Increasing Drug-Resistance to Bacteria Target. | Front Immunol | 2022