Back to search

Peptide record

TPDB09846

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB09846
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia ACP740 _ACP240 AntiCP 2.0 iACP-DRLF AFP-GFuse Antifungipept CAFPdb i2APP APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
FLPKMSTKLRVPYRRGTKDYH
Physicochemical Analysis
C118H189N35O29S1
ANCEQIW
RK
2594.08
10.94
7
1
7
+5
4.62
-1.133
50.95
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
2980
114.88
5
Residue Composition
number
0
A
3
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
0
I
2
L
3
K
1
M
1
F
2
P
1
S
2
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 0 L: 2 K: 3 M: 1 F: 1 P: 2 S: 1 T: 2 W: 0 Y: 2 V: 1
Chemical Descriptors
21
C118H189N35O29S1
2594.08
10.94
+5
4.62
-1.133
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
12.5 ug/mL

Target

Escherichia coli ATCC25629

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.
Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
1.2 ug/mL

Target

Staphylococcus aureus ATCC2576

Source & Reference

dbAMP DRAMP

Other

Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and
Evidence 3 Activity

Activity

MIC
Antibacterial
15 ug/mL

Target

Candida albicans ATCC 300

Source & Reference

dbAMP DRAMP

Other

, resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and C. albicans ATCC 300 (MIC 15 ug/mL). it caused 46.3% histamine release from mast cells at 100 ug/ml.
Evidence 4 Activity

Activity

MIC
Antifungal
12.5 ug/mL

Target

Escherichia coli ATCC25629

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.
Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC
Evidence 5 Activity

Activity

MIC
Antifungal
1.2 ug/mL

Target

Staphylococcus aureus ATCC2576

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and
Evidence 6 Activity

Activity

MIC
Antifungal
15 ug/mL

Target

Candida albicans ATCC 300

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

, resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and C. albicans ATCC 300 (MIC 15 ug/mL). it caused 46.3% histamine release from mast cells at 100 ug/ml.
Evidence 7 Activity

Activity

MIC
Antiparasitic
12.5 ug/mL

Target

Escherichia coli ATCC25629

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiparasitic
DRAMP antiparasitic activity supported by activity records against parasitic targets.
Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC
Evidence 8 Activity

Activity

MIC
Antiparasitic
1.2 ug/mL

Target

Staphylococcus aureus ATCC2576

Source & Reference

DRAMP

Other

Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and
Evidence 9 Activity

Activity

MIC
Antiparasitic
15 ug/mL

Target

Candida albicans ATCC 300

Source & Reference

DRAMP

Other

, resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and C. albicans ATCC 300 (MIC 15 ug/mL). it caused 46.3% histamine release from mast cells at 100 ug/ml.
Evidence 10 Activity

Activity

MIC
Antiviral
12.5 ug/mL

Target

Escherichia coli ATCC25629

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC
Evidence 11 Activity

Activity

MIC
Antiviral
1.2 ug/mL

Target

Staphylococcus aureus ATCC2576

Source & Reference

DRAMP

Other

Active against E. coli ATCC25629 (MIC 12.5 ug/mL), resistant E. coli (MIC 15), S. aureus ATCC2576 (MIC 1.2 ug/mL), resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and
Evidence 12 Activity

Activity

MIC
Antiviral
15 ug/mL

Target

Candida albicans ATCC 300

Source & Reference

DRAMP

Other

, resistant S. aureus (MIC 5), normal ATCC293 and resistant B. dysenteriae (MIC 7.5), and C. albicans ATCC 300 (MIC 15 ug/mL). it caused 46.3% histamine release from mast cells at 100 ug/ml.
Evidence 13 Activity

Activity

% Hemolysis
Hemolysis
2 %
[Ref.19716842]25 ± 2% hemolytic activity at 50 µg/ml against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
Toxicon. 2010 Feb-Mar 55(2-3):274-279.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 14 Activity

Activity

25% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
25% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from centipede venoms. | Toxicon | 2010
Evidence 15 Activity

Activity

21% Hemolysis
Toxicity
50 µg/mL
Hemolytic Cytotoxic
21% Hemolysis | 50 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Two novel antimicrobial peptides from centipede venoms. | Toxicon | 2010
Evidence 16 Activity

Activity

Toxicity
Hemolytic
Hemolytic_activity: [Ref.19716842]25 ± 2% hemolytic activity at 50 µg/ml against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Toxicon. 2010 Feb-Mar 55(2-3):274-279.
Evidence 17 Hemolysis

Activity

2 %
% Hemolysis
[Ref.19716842]25 ± 2% hemolytic activity at 50 µg/ml against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
Toxicon. 2010 Feb-Mar 55(2-3):274-279.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.