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Peptide record

TPDB09844

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09844
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWLDVAKKIGKAAFNVAKNFL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C109H172N28O26
RCEQHMPSTY
AK
2290.74
10.55
4
1
12
+3
0.19
0.262
102.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
2.40
2
Residue Composition
number
4
A
0
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
4
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21 reviewed residue count
C109H172N28O26 sequence-only estimate (linear, free termini)
2290.74 sequence-only estimate (linear, free termini)
10.55 sequence-only estimate (linear, free termini)
+3 sequence-only estimate (linear, free termini)
0.19 sequence-only estimate (linear, free termini)
0.262 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
37.3
[Ref.22391524]HC50=37.3±1.4 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Antimicrob Agents Chemother. 2012 Jun 56(6):3004-10.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
37.3±1.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 37.3±1.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha. | Antimicrob Agents Chemother | 2012
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
0.6±0.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 0.6±0.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha. | Antimicrob Agents Chemother | 2012
Evidence 4 Activity

Activity

HC50
Toxicity
37.3
Hemolytic
Hemolytic_activity: [Ref.22391524]HC50=37.3±1.4 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2012 Jun 56(6):3004-10.
Evidence 5 Hemolysis

Activity

37.3
HC50
[Ref.22391524]HC50=37.3±1.4 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Antimicrob Agents Chemother. 2012 Jun 56(6):3004-10.
DRAMP4
PD_Hemolysis