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Peptide record

TPDB09844

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09844
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 dbAMP DRAMP Peptipedia CAFPdb PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.
Sequence
GWLDVAKKIGKAAFNVAKNFL
Physicochemical Analysis
C109H172N28O26
RCEQHMPSTY
AK
2290.74
10.55
4
1
12
+3
-0.03
0.262
102.38
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
240.10
2
Residue Composition
number
4
A
0
R
2
N
1
D
0
C
0
E
0
Q
2
G
0
H
1
I
2
L
4
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 4 R: 0 N: 2 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 2 K: 4 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
21
C109H172N28O26
2290.74
10.55
+3
-0.03
0.262
Evidence Records 5 records
Evidence 1 Activity

Activity

HC50
Hemolysis
37.3
[Ref.22391524]HC50=37.3±1.4 µmol/L against human red blood cells

Target

human red blood cells

Source & Reference

Hemolytik PD_Hemolysis
DRAMP4
Antimicrob Agents Chemother. 2012 Jun 56(6):3004-10.

Other

Source Activity Label Source Definition
Hemolysis
Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
37.3±1.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 37.3±1.4 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha. | Antimicrob Agents Chemother | 2012
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
0.6±0.1 µM
Hemolytic Cytotoxic
50% Hemolysis | 0.6±0.1 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effects of dimerization on the structure and biological activity of antimicrobial peptide Ctx-Ha. | Antimicrob Agents Chemother | 2012
Evidence 4 Activity

Activity

HC50
Toxicity
37.3
Hemolytic
Hemolytic_activity: [Ref.22391524]HC50=37.3±1.4 µmol/L against human red blood cells

Target

erythrocytes

Source & Reference

NA
DRAMP
Antimicrob Agents Chemother. 2012 Jun 56(6):3004-10.
Evidence 5 Hemolysis

Activity

37.3
HC50
[Ref.22391524]HC50=37.3±1.4 µmol/L against human red blood cells
Hemolysis

Target

human red blood cells

Source & Reference

PD_Hemolysis
Antimicrob Agents Chemother. 2012 Jun 56(6):3004-10.
DRAMP4
PD_Hemolysis