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Peptide record

TPDB09825

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09825
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
AntiBP3 Peptipedia SATPdb dbACP Antifungipept i2APP dbAMP 3.0 APD_complete HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, Peptipedia, SATPdb, and other sources, with an available 3D structural model.
Sequence
FLHHIVGLIHHGLSLFGDRAD
Physicochemical Analysis
C109H164N32O27
NCEQKMPTWY
HL
2354.70
6.48
5
2
10
-1
2.05
0.452
130.00
Mammalian: 1.1 hour Yeast: 3 min E.coli: 2 min
0
0.00
1
Residue Composition
number
1
A
1
R
0
N
2
D
0
C
0
E
0
Q
3
G
4
H
2
I
4
L
0
K
0
M
2
F
0
P
1
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 1 N: 0 D: 2 C: 0 E: 0 Q: 0 G: 3 H: 4 I: 2 L: 4 K: 0 M: 0 F: 2 P: 0 S: 1 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
21
C109H164N32O27
2354.70
6.48
-1
2.05
0.452
Evidence Records 7 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2.5-5 µM

Target

P. immobilisc NCIMB 308

Source & Reference

NA

Other

Active against Gram-negative bacteria Y. ruckeric NCIMB 2196 and P. immobilisc NCIMB 308 (MIC 2.5-5 uM). A recent study synthesized a peptide variant GAD-2 without the last two C-terminal resid
Evidence 2 Activity

Activity

MIC
Antifungal
2.5-5 µM

Target

P. immobilisc NCIMB 308

Source & Reference

Antifungipept

Other

Active against Gram-negative bacteria Y. ruckeric NCIMB 2196 and P. immobilisc NCIMB 308 (MIC 2.5-5 uM). A recent study synthesized a peptide variant GAD-2 without the last two C-terminal resid
Evidence 3 Activity

Activity

MIC
Antiparasitic
2.5-5 µM

Target

P. immobilisc NCIMB 308

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
Active against Gram-negative bacteria Y. ruckeric NCIMB 2196 and P. immobilisc NCIMB 308 (MIC 2.5-5 uM). A recent study synthesized a peptide variant GAD-2 without the last two C-terminal resid
Evidence 4 Activity

Activity

MIC
Antiviral
2.5-5 µM

Target

P. immobilisc NCIMB 308

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against Gram-negative bacteria Y. ruckeric NCIMB 2196 and P. immobilisc NCIMB 308 (MIC 2.5-5 uM). A recent study synthesized a peptide variant GAD-2 without the last two C-terminal resid
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
1.6-0.2 µM
Hemolytic Cytotoxic
10% Hemolysis | 1.6-0.2 | µM | target cell: Cod erythrocytes

Target

Cod erythrocytes

Source & Reference

NA
DBAASP
Differential expression and biological activity of two piscidin paralogues and a novel splice variant in Atlantic cod (Gadus morhua L.). | Fish Shellfish Immunol | 2012
Evidence 6 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Fish Shellfish Immunol. 2012 Mar 32(3):396-406.
Evidence 7 Hemolysis

Source & Reference

APD_complete HemoPI PD_Hemolysis
APD_complete PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation.