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Peptide record

TPDB09810

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB09810

Activity

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

AntiBP3 dbAMP DRAMP Peptipedia Antifungipept CAFPdb AI4AVP dbAMP 3.0 HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from AntiBP3, dbAMP, DRAMP, and other sources, with an available 3D structural model.

Sequence

GLLSGVLGVGKKVLCGLSGLC

FASTA

>TPDB09810|Antibacterial;Anticancer;Antifungal;Antiparasitic;Antiviral;Hemolysis;Toxicity|length=21
GLLSGVLGVGKKVLCGLSGLC

Formula C87H157N23O24S2

Absent Amino Acids ARNDEQHIMFPTWY

Common Amino Acids GL

Mass 1973.46

PI 9.11

Basic Residues 2

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +2

Boman Index -1.33

Hydrophobicity 1.362

Aliphatic Index 152.86

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 6.33

Polar Residues 4

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 6 H: 0 I: 0 L: 6 K: 2 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 3

Length

Formula

C87H157N23O24S2

Mass

1973.46

9.11

Net Charge

Boman Index

-1.33

Hydrophobicity

1.362

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class. DRAMP antibacterial activity supported by MIC records against bacterial target organisms.

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source dbAMP DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class. DRAMP antifungal activity supported by activity records against fungal target organisms.

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-32 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source dbAMP DRAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiparasitic	DRAMP antiparasitic activity supported by activity records against parasitic targets. dbAMP 3.0 classified under the Anti-parasitic function class.

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiparasitic

Activity Measurement 16-32 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 8-16 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Source Activity Label	Source Definition
Antiviral	DRAMP antiviral activity supported by activity records against viral targets. dbAMP 3.0 classified under the Anti-viral function class.

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 128 µg/mL

Target

Target Organism S.enteritidis

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antiviral

Activity Measurement 16-32 µg/mL

Target

Target Organism Staphylococcus aureus ATCC 29213

Source & Reference

Database Source dbAMP 3.0 DRAMP

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 8-16 ug/ml), S.enteritidis (MIC 128 ug/ml), and S. aureus ATCC 29213 (MIC 16-32 ug/ml).

Evidence 13 Activity

Activity

Activity Endpoint % Hemolysis

Detail Source Activity Hemolysis

Activity Measurement 100 %

Hemolysis Raw

[Ref.17272268] RCH=100% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Target

RBC Target rabbit red blood cells

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 14 Activity

Activity

Activity Endpoint 100% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

100% Hemolysis | 50 | µg/mL | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007

Evidence 15 Activity

Activity

Activity Endpoint (30.1±4.4)% degranulation

Detail Source Activity Toxicity

Activity Measurement 50 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

(30.1±4.4)% degranulation | 50 | µg/mL | target cell: Human mast cells

Target

Target Cell Human mast cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Anti-infection peptidomics of amphibian skin | Mol Cell Proteomics | 2007

Evidence 16 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022

Evidence 17 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Hemolytic

Toxicity Raw

Hemolytic_activity: [Ref.17272268] RCH=100% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Evidence 18 Hemolysis

Activity

Activity Measurement 100 %

Activity Endpoint % Hemolysis

Hemolysis Raw

[Ref.17272268] RCH=100% against rabbit red blood cells at 50 µg/ml. RCH, red cell hemolysis.

Detail Source Activity Hemolysis

Target

RBC Target rabbit red blood cells

Source & Reference

source HemoPI PD_Hemolysis

Reference

Mol Cell Proteomics. 2007 May 6(5):882-894.

Source DRAMP4

Database Source PD_Hemolysis