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Peptide record

TPDB09804

Antibacterial Antifungal Hemolysis Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB09804
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
AntiBP3 Peptipedia Antifungipept CAFPdb dbAMP HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 21-aa standard-residue multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from AntiBP3, Peptipedia, Antifungipept, and other sources, with an available 3D structural model.
Sequence
RWCVYAYVRVAGVLVRYRRCW
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C124H188N38O25S2
NDEQHIKMFPST
RV
2675.22
10.44
5
0
13
+5
1.82
0.229
97.14
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
15595
5.83
5
Residue Composition
number
2
A
5
R
0
N
0
D
2
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 2 R: 5 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 3 V: 5
Chemical Descriptors
21 reviewed residue count
C124H188N38O25S2 sequence-only estimate (linear, free termini)
2675.22 sequence-only estimate (linear, free termini)
10.44 sequence-only estimate (linear, free termini)
+5 sequence-only estimate (linear, free termini)
1.82 sequence-only estimate (linear, free termini)
0.229 sequence-only estimate (linear, free termini)
Evidence Records 5 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
12.5 µM
Hemolytic Cytotoxic
0% Hemolysis | 12.5 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. | Biochem Biophys Res Commun | 2011
Evidence 2 Activity

Activity

7% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
7% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. | Biochem Biophys Res Commun | 2011
Evidence 3 Activity

Activity

32% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
32% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. | Biochem Biophys Res Commun | 2011
Evidence 4 Activity

Activity

45% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
45% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The characteristic region of arenicin-1 involved with a bacterial membrane targeting mechanism. | Biochem Biophys Res Commun | 2011
Evidence 5 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis